Results 91 to 100 of about 757,181 (341)

Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen

open access: yesAnemia, 2018
Background. Iron deficiency anemia (IDA) is one of the most common types of nutritional anemia in the worldwide and considered a major public health problem in developing countries especially in Yemen.
Abdullah Ahmed Al-alimi   +2 more
doaj   +1 more source

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway

open access: yesAdvanced Science, EarlyView.
Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li   +8 more
wiley   +1 more source

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

open access: yesAnemia, 2012
Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in the HBB gene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and ...
Mário Angelo Claudino   +1 more
doaj   +1 more source

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.

open access: yesAdvances in Chronic Kidney Disease, 2019
Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism.
Neil S. Sanghani, V. Haase
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen   +6 more
wiley   +1 more source

Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study

open access: yesAnemia, 2012
Introduction. Patients with β-thalassemia intermedia have a higher incidence of thromboembolic events compared to the general population. Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have ...
Nahid Ashjazadeh   +4 more
doaj   +1 more source

Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018.

open access: yesAmerican Journal of Kidney Diseases, 2018
Anemia is a frequent complication during the later stages of chronic kidney disease. When present, it may cause symptoms such as fatigue and shortness of breath.
S. Fishbane, B. Spinowitz
semanticscholar   +1 more source

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

open access: yesAdvanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen   +19 more
wiley   +1 more source

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

open access: yesAnemia, 2012
This paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients.
M. A. Emokpae, P. O. Uadia
doaj   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

open access: yesAdvanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang   +12 more
wiley   +1 more source

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