Results 81 to 90 of about 981,823 (312)

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China

Hematology
Background Luspatercept, approved by the FDA and EMA for patients with transfusion-dependent lower-risk myelodysplastic syndrome (LR-MDS) unresponsive to erythropoiesis-stimulating agents (ESAs), lacks extensive real-world data, particularly in China ...
Weiru Liang, Rui Kang, Yufei Zhao, Lingxiao Xing, Baohang Zhang, Yimeng Shi, Yuan Li, Guangxin Peng, Xin Zhao, Xu Liu, Jing Hu, Xiangrong Hu, Kang Zhou, Yang Yang, Youzhen Xiong, Jianping Li, Huihui Fan, Wenrui Yang, Lei Ye, Liping Jing, Li Zhang, Fengkui Zhang   +21 more
doaj   +1 more source

Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Côte d'Ivoire [PDF]

, 2012
BACKGROUND: Given the widespread distribution of Plasmodium and helminth infections, and similarities of ecological requirements for disease transmission, coinfection is a common phenomenon in sub-Saharan Africa and elsewhere in the tropics. Interactions
A Spiegel, AA Righetti, AH Shankar, Ahou-Yah G. Koua, Aurélie A. Righetti, C Menendez, CJL Murray, D Filmer, DA Ross, DI Thurnham, DL Doolan, Dominik Glinz, EK N'Goran, EK N'Goran, Eliézer K. N'Goran, FC Hartgers, FK Grant, FP Mockenhaupt, Francis Mutuku, G Jones, G Weiss, GC Melo, HR Choudhury, J Langhorne, J Murray, JD Cook, JG Erhardt, JK Kung'u, JL Gorstein, Jürg Utzinger, KE Lyke, KP West Jr, L Brutus, L Serghides, Lukas G. Adiossan, M Nacher, M Zuk, MD Taylor, N Katz, NJ Yatich, NR de Silva, P Galan, PJ Hotez, Richard F. Hurrell, Rita Wegmüller, RJ Stoltzfus, RL Pullan, RM Maizels, RW Snow, S Brooker, S Brooker, SL Becker, Sébastien Niamké, Y Dror   +53 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Integrating Interactive Web-Based Technology to Assess Adherence and Clinical Outcomes in Pediatric Sickle Cell Disease

Anemia, 2012
Research indicates that the quality of the adherence assessment is one of the best predictors for improving clinical outcomes. Newer technologies represent an opportunity for developing high quality standardized assessments to assess clinical outcomes ...
Lori E. Crosby, Ilana Barach, Meghan E. McGrady, Karen A. Kalinyak, Adryan R. Eastin, Monica J. Mitchell   +5 more
doaj   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications

Anemia, 2012
Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation.
Stefan Meyer, Heidemarie Neitzel, Holger Tönnies   +2 more
doaj   +1 more source

Micronutrient Intake and Fundal Height Determine Birth Weight [PDF]

, 2019
The birth weight (BW) are utilized as indicators of the healthy and term newborns. Factor that affects the weight of a newborn are micronutrient intake and fundal height. Folic acid and iron (Fe) were associated with newborn birth weight.
Aghadiati, F. (Faradina), Dewi, Y. L. (Yulia), Hanim, D. (Diffah)   +2 more
core   +3 more sources

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

The Impact of an Algorithm-Guided Management of Preoperative Anemia in Perioperative Hemoglobin Level and Transfusion of Major Orthopedic Surgery Patients

Anemia, 2013
The aim of this study was to evaluate a laboratory-guided therapeutic algorithm of preoperative anemia. 335 patients with elective hip or knee arthroplasty were included in this retrospective before-after study.
Dietmar Enko, Franz Wallner, Achim von-Goedecke, Christa Hirschmugl, Vinzenz Auersperg, Gabriele Halwachs-Baumann   +5 more
doaj   +1 more source