Results 161 to 170 of about 1,053,264 (360)

Hereditary Spherocytosis due to an SPTA1 Nonsense Mutation Coinherited With α spectrinLELY in Trans

open access: yes
American Journal of Hematology, EarlyView.
María‐Angustias Molina‐Arrebola   +1 more
wiley   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

open access: yesAngewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry   +13 more
wiley   +1 more source

MDS/MPN With SF3B1 Mutation and Thrombocytosis but Without Ring Sideroblasts

open access: yes
American Journal of Hematology, EarlyView.
Biswadip Hazarika, Barbara J. Bain
wiley   +1 more source

Hydrogel Composites and Their Potential Application in Animal Production and Health

open access: yesAnimal Research and One Health, EarlyView.
With emerging concerns about environmental contamination and safe animal production practices for increased animal welfare, research has increased in search of alternatives to promote sustainable production. The application of naturally derived hydrogels presents a great opportunity for exploration and application for animal production purposes ...
Victoria Anthony Uyanga   +4 more
wiley   +1 more source

THE GROWTH RESPONSE OF CHICKS TO ANTIPERNICIOUS ANEMIA PREPARATIONS

open access: hybrid, 1949
Charles A. Nichol   +3 more
openalex   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

open access: yesArthritis &Rheumatology, EarlyView.
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen   +2 more
wiley   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled Trial of Abatacept for the Treatment of Relapsing, Nonsevere Granulomatosis With Polyangiitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective To compare the efficacy of abatacept to placebo for the treatment of relapsing, nonsevere granulomatosis with polyangiitis (GPA). Methods In this multicenter trial, eligible patients with relapsing, nonsevere GPA were randomized to receive abatacept 125 mg subcutaneously once a week or placebo, both together with prednisone 30 mg/day (or ...
Carol A. Langford   +155 more
wiley   +1 more source

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