Results 71 to 80 of about 757,181 (341)

Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China

Hematology
Background Luspatercept, approved by the FDA and EMA for patients with transfusion-dependent lower-risk myelodysplastic syndrome (LR-MDS) unresponsive to erythropoiesis-stimulating agents (ESAs), lacks extensive real-world data, particularly in China ...
Weiru Liang, Rui Kang, Yufei Zhao, Lingxiao Xing, Baohang Zhang, Yimeng Shi, Yuan Li, Guangxin Peng, Xin Zhao, Xu Liu, Jing Hu, Xiangrong Hu, Kang Zhou, Yang Yang, Youzhen Xiong, Jianping Li, Huihui Fan, Wenrui Yang, Lei Ye, Liping Jing, Li Zhang, Fengkui Zhang   +21 more
doaj   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Reduced PKC α Activity Induces Senescent Phenotype in Erythrocytes

Anemia, 2012
The molecular mechanism mediating expression of senescent cell antigen-aggregated or cleaved band 3 and externalized phosphatidylserine (PS) on the surface of aged erythrocytes and their premature expression in certain anemias is not completely ...
Rukmini B. Govekar, Poonam D. Kawle, Suresh H. Advani, Surekha M. Zingde   +3 more
doaj   +1 more source

Individual and community level factors associated with anemia among lactating mothers in Ethiopia using data from Ethiopian demographic and health survey, 2016; a multilevel analysis

BMC Public Health, 2020
Background Maternal anemia is a worldwide public health problem especially in developing countries including Ethiopia. The anemia burden among lactating mothers was higher in Africa particularly in Ethiopia, and scant attention was paid.
Alemneh Mekuriaw Liyew, Achamyeleh Birhanu Teshale   +1 more
semanticscholar   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts

Blood Advances, 2018
: We examined outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) using T-cell receptor αβ+ (TCRαβ+)/CD19+-depleted grafts (TCR group, 14 patients) in children with hemoglobinopathies.
Javid Gaziev, Antonella Isgrò, Pietro Sodani, Katia Paciaroni, Gioia De Angelis, Marco Marziali, Michela Ribersani, Cecilia Alfieri, Alessandro Lanti, Tiziana Galluccio, Gaspare Adorno, Marco Andreani   +11 more
doaj  

Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia

Anemia, 2017
Objective. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. Study Design.
Melvin H. Seid, Angelia D. Butcher, Ashwin Chatwani   +2 more
doaj   +1 more source

THE DIAGNOSIS OF ANEMIA. [PDF]

Journal of the American Medical Association, 1907
We may be concerned either with the fact, or with the type. Is anemia present? If so, what kind? The question whether or not anemia is present can be decided only and sufficiently by testing the hemoglobin. We should never assume that anemia is present either from the symptoms alone, or from the appearance of the patient, or from both taken together ...
openaire   +3 more sources

Anemia of spaceflight [PDF]

Blood, 1982
A consistent deficit in the red cell mass has been observed during both the American and Soviet orbital space flights and is sometimes referred to as “astronaut anemia.” This may be associated with a reduction in plasma volume so that the hematocrit and the hemoglobin concentration remain unchanged.
openaire   +3 more sources