Results 131 to 140 of about 1,564,022 (279)

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee   +3 more
wiley   +1 more source

Anesthesia & Analgesia

open access: yes, 2018
Anesthesia & Analgesia is a monthly peer-reviewed medical journal covering anesthesia, pain management, and perioperative medicine that was established in 1922.

core  

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng   +15 more
wiley   +1 more source

Anesthesia and its complications in pregnancy

open access: yes, 2014
The thesis is a review of the indications and contraindications of anesthesia use in women during different stages of pregnancy and the expected outcome and possible complications for the mother and/or the fetus.VÁáltalános orvosangolBSc ...
Osi, Sonia Nnenna
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Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

open access: yesAdvanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang   +11 more
wiley   +1 more source

Use of aerosol isoproterenol in an anesthesia circuit.

open access: yes, 1968
Fresoli, R. P., Smith, R. M., Jr, Young, J. A., & Gottshall, S. C. (1968). Use of aerosol isoproterenol in an anesthesia circuit.
Fresoli, R P   +3 more
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