Results 1 to 10 of about 12,749 (205)
Frontiers in Medicine, 2021 Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic ...
Zhe Cai, Liangyuan Suo, Zeqing Huang
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Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro. [PDF]
PLoS ONE, 2008 The volatile anesthetic isoflurane poses a number of experimental challenges in the laboratory. Due to its rapid evaporation, the open conditions of most in vitro electrophysiological recording systems make the determination of actual isoflurane ...
Stuart J McDougall +5 more
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Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. [PDF]
PLoS ONE, 2014 Isoflurane in clinical use is a racemate of S- and R-isoflurane. Previous studies have demonstrated that the effects of S-isoflurane on relevant anesthetic targets might be modestly stronger (less than 2-fold) than R-isoflurane.
Weiming Bu +3 more
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Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment
Cell Death Discovery, 2021 Ferroptosis is a novel type of programmed cell death, which is different from apoptosis and autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro neurotoxicity induced by isoflurane, which is one of the most common
Pengfei Liu +5 more
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Folia Histochemica et Cytobiologica, 2021 INTRODUCTION: Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.
Yuanyuan Que +5 more
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Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. [PDF]
PLoS ONE, 2015 Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia. Studies have reported widespread sites of action of isoflurane, suggesting a wide array of side effects besides sedation. In the present study,
Kumiko Yonezaki +6 more
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Biomedicines, 2022 The therapeutic effects of volatile anesthetics on mental diseases, particularly schizophrenia, have gained considerable interest. Although isoflurane is a commonly used volatile anesthetic, there’s no more evidence that it could work on treating ...
Hualing Peng +3 more
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Isoflurane and Carbon Dioxide Elicit Similar Behavioral Responses in Rats
Animals, 2020 Euthanasia in rodents is an ongoing topic of debate due to concerns regarding the aversive nature of gases with anesthetic properties such as carbon dioxide (CO2) and isoflurane.
Satyajit Kulkarni, Debra Hickman
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Isoflurane preconditioning confers cardioprotection by activation of ALDH2. [PDF]
PLoS ONE, 2013 The volatile anesthetic, isoflurane, protects the heart from ischemia/reperfusion (I/R) injury. Aldehyde dehydrogenase 2 (ALDH2) is thought to be an endogenous mechanism against ischemia-reperfusion injury possibly through detoxification of toxic ...
Xiao-E Lang +5 more
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Frontiers in Pharmacology, 2022 Background: Electroencephalography (EEG) recordings under propofol exhibit an increase in slow and alpha oscillation power and dose-dependent phase–amplitude coupling (PAC), which underlie GABAA potentiation and the central role of thalamocortical ...
Jingyao Jiang +12 more
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