Results 21 to 30 of about 46,246 (246)

Phase transitions in biological membranes

, 2018
Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung ...
A Blicher, A Blicher, A Gonzalez-Perez, A Gonzalez-Perez, A Hac, A Punnia-Moorthy, AG Lee, AL Hodgkin, AL Hodgkin, B Lautrup, D Johnston, D Papahadjopoulos, DB Mountcastle, DP Kharakoz, E London, EF DeLong, FH Johnson, FH Johnson, GH Kim, GS Manning, H Ebel, H Kamaya, H Kamaya, H Kamaya, H Träuble, HJ Galla, HM Seeger, HM Seeger, I Tasaki, J Gallaher, J Marmur, JE Rothman, JE Rothman, JLCM Vossenberg van de, JM Ritchie, JR Hazel, JR Hazel, JR Trudell, K Græsbøll, K Iwasa, K Iwasa, K Simons, KA Zecchi, KR Laub, L Onsager, LD Mosgaard, LD Mosgaard, LO Ingram, M Gudmand, M Moldovan, MC Sabra, MJ Halsey, MJ Pringle, OG Mouritsen, P Grabitz, PF Almeida, PL Privalov, R Böckmann, R Ravindra, R Winter, RS Cantor, RS Cantor, RW Glaser, S Johnson, SV Avery, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Horishita, Tian Wang, UR Pedersen, Y Kaminoh, Y Zuo   +76 more
core   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Carotid Endarterectomy under Regional (Conductive) Anesthesia

Annals of Surgery, 1982
Carotid endarterectomy is reliable in the prevention of strokes due to arteriosclerotic disease at the carotid bifurcation. This is a retrospective review of 314 carotid endarterectomies performed at the University Health Center of Pittsburgh. The objectives of the study were to determine if regional anesthesia was a safe technique for carotid ...
Jean-michel Loubeau, Marshall W. Webster, Andrew B. Peitzman, Henry T. Bahnson, Betty L. Grundy   +4 more
openaire   +4 more sources

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]

, 2015
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C., Choisy, Stéphanie C., Hancox, Jules C., James, Andrew F., Jones, Sandra A., Kim, Shang-Jin   +5 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

The clinical features of the piriformis syndrome: a systematic review [PDF]

, 2010
Piriformis syndrome, sciatica caused by compression of the sciatic nerve by the piriformis muscle, has been described for over 70 years; yet, it remains controversial. The literature consists mainly of case series and narrative reviews. The objectives of
A Chantraine, A Hulbert, A Ku, A Miller, AG Filler, AH Freiberg, AH Freiberg, AJ Sutton, AM Lewis, B Gandhavadi, B Kumar, BSE Rich, C Steiner, CC Stegbauer, CE Dionne, CW Chang, CW Slipman, D Pokorny, D West, DA Jabs, DL Kent, DR Robinson, E Ernst, E Ernst, E Ernst, E Ernst, EC Papadopoulos, EC Yuen, EM Raney, ER Benson, EW Retzlaff, EY Lee, F Cramp, Fujian Song, G Waddell, GM Wyant, H Nakamura, HF Guyomarc’h, HI Pecina, HT Benzon, HW Park, I Colmegna, I Kosukegawa, IM Merlo, J Dalmau-Carola, J Karppinen, J Kouvalchouk, J Soga, J Young, JA Adams, JA Brown, JB Pace, JD Stewart, JJ Jankiewicz, JK Silver, JP Vandenbroucke, JS Kirschner, JWT Byrd, K Hopayian, K Indrekvam, K Konstantinou, Kevork Hopayian, KJ Stevens, KW Chong, L Jroundi, LF Solheim, LM Fishman, LM Fishman, LM Fishman, M Hanania, M Jenicek, M Pecina, M Tulder van, MC Vallejo, ME Julsrud, MR Foster, MR Foster, MW Cook, N Mayrand, NA Broadhurst, OA El Rubaidi, P Kobbe, P Limongelli, P Rossi, PM Barton, PM Bossuyt, R Dhote, RA Beatty, RD Karl Jr, Ricardo Riera, RJ Spinner, RL Tiel, RL Tiel, RP Beauchesne, RP Hallin, RR Richardson, S Bustamante, S Ozaki, S Turtas, SC Sayson, Sidha Sambandan, SJ Yoon, SM Papadopoulos, SM Papadopoulos, SS Hughes, T Banerjee, T Rodrigue, TN Bernard, TS Carey, V Rucco, VM Synek, VM Synek, WJ Mixter, WP Vandertop, WS Chen, WS Chen, WS Chen, Z Durrani   +117 more
core   +2 more sources

Observational Study of Tocilizumab in Children With Febrile Infection‐Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to assess the efficacy and safety of using tocilizumab in children with febrile infection‐related epilepsy syndrome (FIRES) and explore tocilizumab‐related changes in interleukin (IL)‐6 levels. Methods Patients with FIRES admitted to the Intensive Care Unit (ICU) of Beijing Children's Hospital were retrospectively ...
Yushan He, Jie Wu, Chaonan Fan, Zheng Li, Jun Liu, Kechun Li, Quan Wang, Suyun Qian   +7 more
wiley   +1 more source

Role of Catheter Ablation in Arrhythmogenic Right Ventricular Dysplasia [PDF]

, 2005
Arrhythmogenic right ventricular dysplasia/cardiomyopathy is a disorder characterized by frequent ventricular tachycardia originating from the right ventricle and fibro-fatty replacement of right ventricular myocardium. Though the disorder was originally
Fontaine, Guy, Francis, Johnson
core   +2 more sources

Generation of theta activity (RSA) in the cingulate cortex of the rat [PDF]

, 1982
Unit activity recorded from the cingulate cortex during theta rhythm shows periodic trains of spikes which are phase-locked to the local theta field potential waves. These cortical theta units were also shown to be correlated with hippocampal theta units.
Holsheimer, J.
core   +3 more sources