Results 71 to 80 of about 837,779 (311)

Seizure control of current shunt on rats with temporal lobe epilepsy and neocortical epilepsy. [PDF]

open access: yesPLoS ONE, 2014
PURPOSE: To examine the effects of current shunt on rats with temporal lobe epilepsy and neocortex epilepsy. EXPERIMENTAL DESIGN: A kainic acid (KA)-induced model of temporal lobe seizure and a penicillin-induced model of neocortical partial seizure were
Limin Zhang   +8 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Quantification of depth of anesthesia by nonlinear time series analysis of brain electrical activity [PDF]

open access: yes, 2000
We investigate several quantifiers of the electroencephalogram (EEG) signal with respect to their ability to indicate depth of anesthesia. For 17 patients anesthetized with Sevoflurane, three established measures (two spectral and one based on the bispectrum), as well as a phase space based nonlinear correlation index were computed from consecutive EEG
arxiv   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

open access: yesFEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo   +6 more
wiley   +1 more source

In Vivo Changes in Canine Ventricular Cardiac Conduction during Halothane Anesthesia

open access: yesAnesthesia and Analgesia, 1980
Changes in the ventricular conduction system associated with halothane anesthesia were investigated by direct methods of His bundle recording, pacing, and premature stimulation in a canine model.
L. Turner   +3 more
semanticscholar   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

Modification of classification of methods of local anesthesia

open access: yesЭндодонтия Today, 2020
Given the proven in a series of recent scientific papers leading vascular component of the mechanism of spongy injections, traditional classification techniques of dental local anesthesia needs to be transformed.

doaj  

A survey of the practice of regional anesthesia in Saudi Arabia

open access: yesSaudi Journal of Anaesthesia, 2013
Objective: This survey aimed to assess both the extent of practice and need for training in regional anesthesia among anesthesiologists in Saudi Arabia in 2012.
Mohammed Al Harbi   +5 more
doaj   +1 more source

Multiple Instance Segmentation in Brachial Plexus Ultrasound Image Using BPMSegNet [PDF]

open access: yesarXiv, 2020
The identification of nerve is difficult as structures of nerves are challenging to image and to detect in ultrasound images. Nevertheless, the nerve identification in ultrasound images is a crucial step to improve performance of regional anesthesia.
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

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