Results 91 to 100 of about 54,521 (292)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

A Self-Directed Review of Anatomy Related to Local Anesthesia

MedEdPORTAL, 2010
Introduction This module contains a self-directed review of anatomy related to local anesthesia with emphasis on skull and anatomical considerations. The primary goal is to provide a focused review of relevant anatomy and landmarks to assist the dental ...
Terry Dean
doaj   +1 more source

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

Advanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao, Yijia Yin, Fangyuan Shuai, Waishan Lam, Tao Zhou, Yaxin Xie, Xuesong He, Xianglong Han   +7 more
wiley   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

ToF-SIMS Investigations on Dental Implant Materials and Adsorbed Protein Films [PDF]

arXiv, 2011
In this work the two experimental dental implant materials FAT and FAW, made of fluoroapatite particles embedded in polymer matrices, and films of the proteins lysozyme, amylase and bovine serum albumin (BSA), adsorbed to the two dental implant materials, were investigated with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and the ...
arxiv  

STRESS-INDUCED VARIABILITY IN LOCAL ANESTHESIA RESPONSE: EXPLORING IMPLICATIONS FOR DENTAL ANESTHETIC MANAGEMENT

Romanian Journal of Oral Rehabilitation
This article delves into the intricate relationship between stress, dental anxiety, and the variability in local anesthesia response, elucidating its impact on pain management and treatment outcomes in dentistry.
Carmen Grierosu, Cozmin Mihai, Ionut Iulian Lungu, Gabriela Calin, Alina Stefanache, Mihaela Papusa Vasiliu, Gabriela Liliana Haliţchi, Daniela Ivona Tomiţa, Diana Mihaela Gheban, Codrin Paul Fuioaga, Norin Forna, Carmen Stadoleanu   +11 more
doaj   +1 more source

Propofol attenuates odontogenic/osteogenic differentiation of human dental pulp stem cells in vitro

Journal of Dental Sciences, 2022
Background/purpose: Various studies have used stem cells in the field of bone tissue engineering to repair bone defects. Dental pulp stem cells (DPSCs) have multipotent properties and can be acquired in a noninvasive manner; therefore, they are ...
Eun-Ji Choi, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim, Ji-Uk Yoon, Ah-Reum Cho, Eun-Jung Kim   +7 more
doaj  

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

Advanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing, Shuang Liang, Wei Cao, Qulian Guo, Wangyuan Zou   +4 more
wiley   +1 more source

Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Advanced Science, EarlyView.
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin, Fei He, Haad Rathore, Yingchu Sun, Jia‐ao Zhang, Xinyu Li, Rongkang Yin, Hanlin Zhu, Chong Xie, Lan Luan   +9 more
wiley   +1 more source

Expanding the phenotype in Pitt-Hopkins syndrome; description of new oral finding and dental management considerations

BMC Oral Health
Background Pitt-Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder with physical, cognitive, and behavioral characteristics that is caused by heterozygous mutations in the TCF4 gene. Patients with PTHS might present a unique challenge for oral
Yazan Hassona, Dua’a Alqaisi, Asma Alkilani, Iyas AbuHijleh   +3 more
doaj   +1 more source