Results 111 to 120 of about 105,924 (291)

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity

Advanced Science, EarlyView.
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang, Nuo Xu, Wenwen Wang, Yongxiang He, Yuqian Yang, Liuning Zhang, Yanping Zou, Yuehua He, Huiliang Li, Liang Gao, Lin Xiao   +10 more
wiley   +1 more source

Impact of Sensory Adapted Dental Environment on Children with Developmental Disabilities [PDF]

, 2018
Purpose: This was a pilot study assessing the impact of a sensory adapted dental environment (SADE) on children with developmental disabilities (DD) receiving routine dental care.
Kim, Gail
core   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

Expanding the phenotype in Pitt-Hopkins syndrome; description of new oral finding and dental management considerations

BMC Oral Health
Background Pitt-Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder with physical, cognitive, and behavioral characteristics that is caused by heterozygous mutations in the TCF4 gene. Patients with PTHS might present a unique challenge for oral
Yazan Hassona, Dua’a Alqaisi, Asma Alkilani, Iyas AbuHijleh   +3 more
doaj   +1 more source

Replication of Known Dental Characteristics in Porcine Skin: Emerging Technologies for the Imaging Specialist [PDF]

, 2014
This study demonstrates that it is sometimes possible to replicate patterns of human teeth in pig skin and determine scientifically that a given injury pattern (bite mark) correlates with the dentitions of a very small proportion of a population dataset,
Ahn, Kwang Woo, Corliss, George, Groffy, Ronald L., Jeutter, Dean C, Johnson, L. Thomas, Radmer, Thomas W, Stafford, Gary L, Thulin, Joseph, Visotky, Alexis, Wirtz, Thomas   +9 more
core   +1 more source

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Advanced Science, EarlyView.
This study introduces a miniaturized wireless neural recording system integrated with custom‐designed 120‐channel µECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The system can capture and characterize behavior‐specific neural signals, including drinking‐related activation, pre‐vocalization anticipatory responses,
Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao, Xinjian Li, Mingjun Zhang   +22 more
wiley   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

A randomized controlled trial to assess parental satisfaction with computerized intraosseous anesthesia versus inferior alveolar nerve block in children

Scientific Reports
This study aimed to compare parental satisfaction between two pediatric dental anesthesia techniques, computerized intraosseous anesthesia (CIA) and inferior alveolar nerve block (IANB).
Muaaz Alkhouli, Zuhair Al-Nerabieah, Mayssoon Dashash   +2 more
doaj   +1 more source