Results 91 to 100 of about 11,601,727 (294)

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

A Randomized Comparison among 0.67 μg/kg, 1 μg/ kg and 1.33 μg/kg of Perineural Dexmedetomidine for Ultrasound-guided Infraclavicular Block

Siriraj Medical Journal
Objective: This randomized trial compared three doses of perineural dexmedetomidine for ultrasound-guided infraclavicular block: 0.67 μg/kg (D1), 1 μg/kg (D2), and 1.33 μg/kg (D3), using an identical admixture of 35 mL of lidocaine 1%- bupivacaine 0.25%-
Samita Pirotesak, Daniah Ghareeb Dhaifallah, Mohamed Alem, Anas Alkhoutani, Alexander Amir, Karoll Rodelo, Juan Francisco Asenjo, Roderick J Finlayson, Julián Aliste, De Q Tran   +9 more
doaj   +1 more source

Outcome After General Anesthesia Versus Monitored Anesthesia Care in Transfemoral Transcatheter Aortic Valve Replacement

, 2016
To evaluate outcomes of monitored anesthesia care (MAC) compared with general anesthesia (GA) in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR)
Bontempi, Katia, Biancari, F, Barbanti, Marco, Ranucci, M, Nardi, P, Covello, RD, Onorati, F, Grossi, Claudio, Santini, Francesco, D'Errigo, P, Tamburino, Corrado, Nardi P, Onorati, Francesco, Pisano, C, Seccareccia, F, Ruvolo, G, Covello, Remo Daniel, Santoro, Gennaro, Biancari, Fausto, Santini, F, Tamburino, C, Bontempi, K, Santoro, G, Fusco, D, Rosato, S, Rosato, Stefano, D'Errigo, Paola, Observant Research Group, Barbanti, M, Grossi, C, Fusco, Danilo, Seccareccia, Fulvia, Ranucci, Marco, Bontempi K, Grossi C, Santini F, Covello RD, Barbanti M, Onorati F, Ranucci M, D'Errigo P, Seccareccia F, Rosato S, Fusco D, Santoro G, Biancari F   +45 more
core   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Dexmedetomidine inhibits the lipopolysaccharide‐stimulated inflammatory response in microglia through the pathway involving TLR4 and NF‐κB

Kaohsiung Journal of Medical Sciences, 2019
To investigate the effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)‐induced neuroinflammation in BV2 microglia. BV2 microglial cells were treated with various concentrations of DEX (0, 1, 10, and 100 ng/mL) for 1 hour, and then incubated in ...
Xue‐Yue Zhou, Jing Liu, Zhi‐Peng Xu, Qiang Fu, Pei‐Qi Wang, Hong Zhang   +5 more
doaj   +1 more source

In-hospital mortality does not increase in patients aged over 85 years after hip fracture surgery. A retrospective observational study in a Japanese tertiary hospital

JA Clinical Reports, 2018
Introduction Hip fracture is a common and serious orthopedic injury among the geriatric population, necessitating surgical treatment. We tested whether age is a significant risk factor for in-hospital mortality after surgery in this retrospective cohort ...
Yoshihisa Fujita, Kumi Shimada, Tomohiko Sato, Masahiko Akatsu, Koichi Nishikawa, Atsuko Kanno, Toshitake Aizawa   +6 more
doaj   +1 more source

Spinal anesthesia instead of general anesthesia for infants undergoing tendon Achilles lengthening

, 2018
Mohammad AlSuhebani,1 David P Martin,1,2 Lance M Relland,1,2 Tarun Bhalla,1,2 Allan C Beebe,3 Amanda T Whitaker,3 Walter Samora,3 Joseph D Tobias1,2 1Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, Columbus, OH ...
AlSuhebani M, Beebe AC, Tobias JD, Relland LM, Samora W, Bhalla T, Martin DP, Whitaker AT   +7 more
core  

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

Journal of Neuroinflammation, 2019
Background It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory ...
Weixing Zhao, Zhipeng Xu, Jiangbei Cao, Qiang Fu, Yishuang Wu, Xiaoying Zhang, Yue Long, Xuan Zhang, Yitian Yang, Yunfeng Li, Weidong Mi   +10 more
doaj   +1 more source

A lung rescue team improves survival in obesity with acute respiratory distress syndrome

Critical Care, 2020
Background Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether an individualized titration of
Gaetano Florio, Matteo Ferrari, Edward A. Bittner, Roberta De Santis Santiago, Massimiliano Pirrone, Jacopo Fumagalli, Maddalena Teggia Droghi, Cristina Mietto, Riccardo Pinciroli, Sheri Berg, Aranya Bagchi, Kenneth Shelton, Alexander Kuo, Yvonne Lai, Abraham Sonny, Peggy Lai, Kathryn Hibbert, Jean Kwo, Richard M. Pino, Jeanine Wiener-Kronish, Marcelo B. P. Amato, Pankaj Arora, Robert M. Kacmarek, Lorenzo Berra, For the investigators of the lung rescue team   +24 more
doaj   +1 more source