Results 111 to 120 of about 69,772 (290)

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

open access: yesAdvanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang   +8 more
wiley   +1 more source

Inhalation anesthesia [PDF]

open access: yes
In this paper I will give a somewhat brief report of the high lights of the history of anaesthesia, followed by a generalized description of the various general inhalation anesthetics, their action on the human organism, and the administration of these ...
Baldwin, Ellen
core   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin   +10 more
wiley   +1 more source

Anesthetic and analgesic management of a skunk (Mephitis mephitis) undergoing a laminectomy for cauda equina compression [PDF]

open access: yes, 2010
A 6-year-old, male striped skunk (Mephitis mephitis) weighing 5.9 kg was anesthetized for diagnostic imaging procedures and subsequently for a laminectomy at level L6/S1 as treatment of lumbosacral stenosis. On both occasions, anesthesia was induced by a
Gozalo Marcilla, Miguel   +5 more
core  

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

open access: yesAdvanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo   +13 more
wiley   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong   +15 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

open access: yes, 1969
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1032/thumbnail ...

core   +1 more source

In Vivo Dynamic Coronary Arteries Blood Flow Imaging Based on Multi‐Cycle Phase Clustering Ultrafast Ultrasound

open access: yesAdvanced Science, EarlyView.
This study addresses a critical gap in ultrafast ultrasound cardiovascular flow imaging and introduces a transformative approach, Clustering Singular Value Decomposition (cSVD), which enables dynamic cardiovascular flow imaging throughout full cardiac cycle without motion correction and hyper‐fast imaging strategies.
Hao Yu   +6 more
wiley   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

open access: yesAdvanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong   +12 more
wiley   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

open access: yesAdvanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng   +9 more
wiley   +1 more source

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