Results 1 to 10 of about 37,501 (234)

Increased NMDA receptor inhibition at an increased Sevoflurane MAC [PDF]

BMC Anesthesiology, 2012
Background Sevoflurane potently enhances glycine receptor currents and more modestly decreases NMDA receptor currents, each of which may contribute to immobility.
Brosnan Robert J, Thiesen Roberto
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Bumetanide attenuates sevoflurane‐induced neuroapoptosis in the developing dentate gyrus and impaired behavior in the contextual fear discrimination learning test

Brain and Behavior, 2022
Introduction Sevoflurane acts as a gamma‐aminobutyric acid subtype A receptor agonist and can induce widespread apoptosis of immature dentate granule cells in postnatal day 21 mice.
Kai Wei, Yiheng Liu, Xiamin Yang, Jin Liu, Yuan Li, Meng Deng, Yingwei Wang   +6 more
doaj   +1 more source

Sevoflurane Inhibits Metastasis in Hepatocellular Carcinoma by Inhibiting MiR-665-Induced Activation of the ERK/MMP Pathway

Cell Transplantation, 2022
Recent evidence has indicated that inhalational anesthetics may affect the growth and malignant potential of tumor cells and ultimately influence tumor recurrence after surgery.
Xiaoyan Zhu, Chuchu Peng, Zhiyong Peng, Ruimin Chang, Qulian Guo   +4 more
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Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

Medicina, 2022
Background and Objectives: Clinically used concentrations of sevoflurane, an inhaled anesthetic, have been reported to significantly inhibit tumor growth.
Tomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
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Therapeutic effects of intravenous administration of bone marrow stromal cells on sevoflurane-induced neuronal apoptosis and neuroinflammation in neonatal rats [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundSevoflurane exposure during the early postnatal period causes neuroinflammation and neuronal apoptosis in rodents. Bone marrow stromal cells (BMSCs) have been shown to protect and repair the damaged central nervous system, for example in ...
ZhongLiang Sun, Maiko Satomoto, Koshi Makita   +2 more
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Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Frontiers in Neuroscience, 2022
Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment.
Linhong Zhong, Xiaofan Ma, Yixuan Niu, Lei Zhang, Zhenyu Xue, Jia Yan, Hong Jiang   +6 more
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Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation

BMC Anesthesiology, 2009
Background Sevoflurane has been demonstrated to vasodilate the foeto-placental vasculature. We aimed to determine the contribution of modulation of potassium and calcium channel function to the vasodilatory effect of sevoflurane in isolated human ...
Jarman James, Maharaj Chrisen H, Higgins Brendan D, Farragher Rachel F, Laffey Christopher D, Flynn Noel M, Laffey John G   +6 more
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Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

Frontiers in Psychiatry, 2018
Sevoflurane is one of the most commonly used volatile anaesthetics for children, but the safety of prolonged or repeated clinical use of sevoflurane in infants or children is controversial.
Fu-Yi Shen, Ying-Cai Song, Fei Guo, Zhen-Dong Xu, Qian Li, Bing Zhang, Bing Zhang, Bing Zhang, Yu-Qin Ma, Yu-Qin Ma, Yue-Qi Zhang, Rong Lin, Yang Li, Zhi-Qiang Liu   +13 more
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miR-424 inhibits apoptosis and inflammatory responses induced by sevoflurane through TLR4/MyD88/NF-κB pathway

BMC Anesthesiology, 2022
Background Side effects of sevoflurane in anterograde and retrograde memory have been widely reported. However, there is no convincing evidence that sevoflurane directly causes the development of neurotoxicity.
Zeyu Li, Tao Wang, Yonghao Yu
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Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels

Frontiers in Pharmacology, 2021
Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane.
Linlin Han, Shuai Zhao, Feng Xu, Yafeng Wang, Ruihui Zhou, Shiqian Huang, Yuanyuan Ding, Daling Deng, Weike Mao, Xiangdong Chen   +9 more
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