Results 21 to 30 of about 60,245 (274)

Sevoflurane [PDF]

F1000Research, 2015
Sevoflurane has been available for clinical practice for about 20 years. Nowadays, its pharmacodynamic and pharmacokinetic properties together with its absence of major adverse side effects on the different organ systems have made this drug accepted worldwide as a safe and reliable anesthetic agent for clinical practice in various settings.
Stefan De Hert, Anneliese Moerman
openaire   +3 more sources

Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial.

British Journal of Anaesthesia, 2023
BACKGROUND Delirium is a common and disturbing postoperative complication that might be ameliorated by propofol-based anaesthesia. We therefore tested the primary hypothesis that there is less delirium after propofol-based than after sevoflurane-based ...
Shuang-Jie Cao, Yue Zhang, Yu-Xiu Zhang, Wei Zhao, L. Pan, Xu-De Sun, Zhen Jia, W. Ouyang, Qingxiu Ye, Fang Zhang, Yongjuan Guo, Yan-Qiu Ai, Bin-Jiang Zhao, Jianming Yu, Zhi-Heng Liu, Ning Yin, Xueying Li, Jiayue Ma, Hui-juan Li, Mei-Rong Wang, Daniel I. Sessler, D. Ma, Dong-Xin Wang   +22 more
semanticscholar   +1 more source

Sevoflurane Aggravates the Progress of Alzheimer’s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway

Frontiers in Cell and Developmental Biology, 2022
Background: Alzheimer’s disease (AD) is the most common form of dementia worldwide. Previous studies have reported that sevoflurane, a frequently used anesthetic, can induce cognitive impairment in preclinical and clinical settings.
Dingyuan Tian, Yanmei Xing, Wenli Gao, Hongyan Zhang, Yifeng Song, Ya Tian, Zhongliang Dai   +6 more
semanticscholar   +1 more source

Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis.

Free Radical Biology & Medicine, 2022
Mitochondria damage and apoptosis were found associated with sevoflurane induced neurotoxicity in developing brains of rodent and neuro cell lines. The detailed upstream mechanism remains unclear.
Jinsheng Liu, Li Li, P. Xie, Xiaoyan Zhao, Dongjing Shi, Yan Zhang, Chuxiong Pan, Tianzuo Li   +7 more
semanticscholar   +1 more source

Sevoflurane Preconditioning Increases Stress Resistance via IMB-2/DAF-16 in Caenorhabditis Elegans

Dose-Response, 2022
Sevoflurane preconditioning has been proved to possess therapeutic effects on stress. However, the mechanism by which sevoflurane preconditioning protects against stress remains unclear.
Yue Cao MMed, Yongchen Cui MMed, Junling Liao MMed, Chente Gao MMed, Zhe Zhao MD, Junfeng Zhang MD   +5 more
doaj   +1 more source

Mechanistic insight into sevoflurane-associated developmental neurotoxicity

Cell Biology and Toxicology, 2021
With the development of technology, more infants receive general anesthesia for surgery, other interventions, or clinical examination at an early stage after birth.
Mingyang Sun, Zhongcong Xie, Jiaqiang Zhang, Y. Leng   +3 more
semanticscholar   +1 more source

Nucleus accumbens neurons expressing dopamine D1 receptors modulate states of consciousness in sevoflurane anesthesia.

Current Biology, 2021
Although general anesthesia (GA) enables patients to undergo surgery without consciousness, the precise neural mechanisms underlying this phenomenon have yet to be identified. In addition to many studies over the past two decades implicating the thalamus,
Weimin Bao, Wei Xu, G. Pan, Tian-xiao Wang, Yuan Han, Wei-min Qu, Wenxiang Li, Zhi-Li Huang   +7 more
semanticscholar   +1 more source

NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2

Open Life Sciences, 2023
Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been
Zhong Yuanping, Zhao Pengcheng, Zhang Chao, Wu Zhenyu, Fang Xu, Zhu Zhaoqiong   +5 more
doaj   +1 more source

Inhibition of Adult Hippocampal Neurogenesis Plays a Role in Sevoflurane-Induced Cognitive Impairment in Aged Mice Through Brain-Derived Neurotrophic Factor/Tyrosine Receptor Kinase B and Neurotrophin-3/Tropomyosin Receptor Kinase C Pathways

Frontiers in Aging Neuroscience, 2022
Sevoflurane anesthesia induces cognitive impairment, which may lead to perioperative neurocognitive disorders (PND). However, the factors and molecular mechanism underlying this impairment remains unclear.
Lichi Xu, Yanjing Guo, Yanjing Guo, Gongming Wang, Gongming Wang, Guoqing Sun, Guoqing Sun, Wei Sun, Wei Sun, Jingjing Li, Xinlei Li, Jiangnan Wu, Mengyuan Zhang, Mengyuan Zhang   +13 more
doaj   +1 more source

Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus. [PDF]

PLoS ONE, 2013
BACKGROUND: Our previous studies revealed that application of the inhalation anesthetic, sevoflurane, reversibly repressed the expression of Per2 in the mouse suprachiasmatic nucleus (SCN). We aimed to examine whether sevoflurane directly affects the SCN.
Megumi Anzai, Norio Iijima, Shimpei Higo, Ken Takumi, Izumi Matsuo, Keisuke Mori, Yumiko Ohe, Kana Kadota, Toshio Akimoto, Atsuhiro Sakamoto, Hitoshi Ozawa   +10 more
doaj   +1 more source