Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines [PDF]
, 2020 Purpose: There have been contradictory findings regarding the effects of sevoflurane on the oncogenic properties of cancer cells. This study was conducted to gain insights into the fundamental rules governing the differential effects of sevoflurane ...
Hirai, Takahiro +5 more
core +1 more source
The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aminolah Vasigh +4 more
doaj +1 more source
British Journal of Anaesthesia, 2021 BACKGROUND Sevoflurane anaesthesia induces phosphorylation of the microtubule-associated protein tau and cognitive impairment in neonatal, but not adult, mice. The underlying mechanisms remain largely to be determined. Sex hormones can be neuroprotective,
Yongya Yang +8 more
semanticscholar +1 more source
Protective effects of sevoflurane in cerebral ischemia reperfusion injury: a narrative review
Medical Gas Research, 2021 Ischemia/reperfusion (I/R) injury is a phenomenon that the reperfusion of ischemic organs or tissues aggravates their damage, which poses a serious health threat and economic burden to the world.
Tianyu Liang +5 more
semanticscholar +1 more source
British Journal of Anaesthesia, 1996 Sevoflurane is a fluoridated derivative of methyl isopropyl ether. Its administration does not require the use of sophisticated vaporizers and its blood/gas partition coefficient is 0.69. Sevoflurane is the only ethereal anesthesia that does not trigger a reflex response or cause airway irritation during inhaled induction.
F, Gilsanz +3 more
openaire +4 more sources
The anesthetic sevoflurane induces tau trafficking from neurons to microglia
Communications Biology, 2021 Accumulation and spread of tau in Alzheimer’s disease and other tauopathies occur in a prion-like manner. However, the mechanisms and downstream consequences of tau trafficking remain largely unknown.
Yuanlin Dong +8 more
semanticscholar +1 more source
Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. [PDF]
PLoS ONE, 2018 Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species ...
Julie Wagner +7 more
doaj +1 more source
miRNA‐384‐3p alleviates sevoflurane‐induced nerve injury by inhibiting Aak1 kinase in neonatal rats
Brain and Behavior, 2022 Objective Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation. Increasing studies have revealed that sevoflurane has neurotoxic effects on neurons, apoptosis, and memory
Yuanyuan Chen, Xuan Gao, Hao Pei
doaj +1 more source
Comparison of emergence agitation between sevoflurane/nitrous oxide administration and sevoflurane administration alone in children undergoing adenotonsillectomy with preemptive ketorolac [PDF]
Korean Journal of Anesthesiology, 2014 BackgroundSevoflurane anesthesia commonly causes emergence agitation (EA) in children. One previous study has reported that the use of nitrous oxide (N2O) during the washout of sevoflurane may reduce EA by decreasing the residual sevoflurane ...
Ji Hye Park +6 more
doaj +1 more source
Tau contributes to sevoflurane-induced neurocognitive impairment in neonatal mice
Anesthesiology, 2020 Background: Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This study tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria–adenosine triphosphate ...
Yang Yu +13 more
semanticscholar +1 more source