Sevoflurane and cardioprotection [PDF]
British Journal of Anaesthesia, 2008 The authors hypothesize that the cardioprotective effect of sevoflurane administered throughout CABG operation may be time- and dose-dependent.
L. Siracusano +3 more
openaire +4 more sources
Folia NeuropathologicaSevoflurane is an inhalation anaesthetic agent widely used in clinical settings. Despite good surgical outcomes using sevoflurane, patients frequently develop postoperative cognitive dysfunction (POCD).
Wenfeng Gao +5 more
doaj +2 more sources
Neonatal Sevoflurane Exposure Induces Long-Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2. [PDF]
Adv Sci (Weinh)Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Liang L +11 more
europepmc +2 more sources
miRNA‐384‐3p alleviates sevoflurane‐induced nerve injury by inhibiting Aak1 kinase in neonatal rats
Brain and Behavior, 2022 Objective Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation. Increasing studies have revealed that sevoflurane has neurotoxic effects on neurons, apoptosis, and memory
Yuanyuan Chen, Xuan Gao, Hao Pei
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Mediators of Inflammation, 2020 To investigate the mechanism dexmedetomidine in relieving the neurotoxicity of a developing brain induced by sevoflurane. Sprague-Dawley rats, 6 days old, were randomly divided into three groups.
Yunxia Dong +5 more
doaj +1 more source
Comparison of emergence agitation between sevoflurane/nitrous oxide administration and sevoflurane administration alone in children undergoing adenotonsillectomy with preemptive ketorolac [PDF]
Korean Journal of Anesthesiology, 2014 BackgroundSevoflurane anesthesia commonly causes emergence agitation (EA) in children. One previous study has reported that the use of nitrous oxide (N2O) during the washout of sevoflurane may reduce EA by decreasing the residual sevoflurane ...
Ji Hye Park +6 more
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Journal of Pharmacological Sciences, 2021 Objective: To investigate the effect of sevoflurane on inflammation of microglia in hippocampus of neonatal rats, and to investigate whether the related mechanism is related to Wnt/β-Catenin/CaMKIV pathway. Methods: Neonatal rats were anesthetized with 2%
Fengjuan Wang +3 more
doaj +1 more source
Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect.
Fernanda Paula Cavalcante +7 more
doaj +2 more sources
Neuroprotective effects of sevoflurane against electromagnetic pulse-induced brain injury through inhibition of neuronal oxidative stress and apoptosis. [PDF]
PLoS ONE, 2014 Electromagnetic pulse (EMP) causes central nervous system damage and neurobehavioral disorders, and sevoflurane protects the brain from ischemic injury. We investigated the effects of sevoflurane on EMP-induced brain injury.
Bin Deng +11 more
doaj +1 more source
The effects of midazolam and sevoflurane on the GABA receptors with alternatively spliced variants of the γ2 subunit [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundEmergence agitation after sevoflurane anesthesia in children can be prevented by midazolam. Alternative splicing of the GABAA receptor changes with age.
Woosik Eom +5 more
doaj +1 more source