Results 11 to 20 of about 60,245 (274)
Frontiers in Medicine, 2022 Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in developing hippocampus.
Yeru Chen, Zhang Piao
exaly +4 more sources
Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
Frontiers in Aging Neuroscience, 2021 Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD ...
Shu Lin, Hefan He, He He-Fan
exaly +2 more sources
Journal of Pharmacological Sciences, 2021 Objective: To investigate the effect of sevoflurane on inflammation of microglia in hippocampus of neonatal rats, and to investigate whether the related mechanism is related to Wnt/β-Catenin/CaMKIV pathway. Methods: Neonatal rats were anesthetized with 2%
Fengjuan Wang +3 more
doaj +2 more sources
The Mechanisms of Sevoflurane-Induced Neuroinflammation
Frontiers in Aging Neuroscience, 2021 Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell.
Fuzhou Hua, Pu Fang, Wang Xifeng
exaly +2 more sources
Mediators of Inflammation, 2020 To investigate the mechanism dexmedetomidine in relieving the neurotoxicity of a developing brain induced by sevoflurane. Sprague-Dawley rats, 6 days old, were randomly divided into three groups.
Yunxia Dong +5 more
doaj +2 more sources
British Journal of Anaesthesia, 2018 Background: The choice of general anaesthetics may affect postoperative cognitive outcomes. This study was designed to compare the potential impact of propofol‐based vs sevoflurane‐based general anaesthesia on the development of delayed neurocognitive ...
Youyi Zhang +7 more
exaly +2 more sources
An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia [PDF]
Folia NeuropathologicaSevoflurane is an inhalation anaesthetic agent widely used in clinical settings. Despite good surgical outcomes using sevoflurane, patients frequently develop postoperative cognitive dysfunction (POCD).
Wenfeng Gao +5 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2020 The safety of volatile anesthetics in infants and young children has been drawing increasing concern due to its potential neurotoxicity in the developing brain. Neuronal death is considered a major factor associated with developmental neurotoxicity after
Meihua Piao +7 more
doaj +2 more sources
Increased NMDA receptor inhibition at an increased Sevoflurane MAC [PDF]
BMC Anesthesiology, 2012 Background Sevoflurane potently enhances glycine receptor currents and more modestly decreases NMDA receptor currents, each of which may contribute to immobility.
Brosnan Robert J, Thiesen Roberto
doaj +3 more sources
Chinese Journal of Physiology, 2023 Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs).
Minmin Cai, Xiang Gao, Shenghui Yu
doaj +1 more source