Results 11 to 20 of about 37,501 (234)

Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration

Frontiers in Medicine, 2022
Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in developing hippocampus.
Yeru Chen, Zhang Piao
exaly   +3 more sources

An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia

Folia Neuropathologica
Sevoflurane is an inhalation anaesthetic agent widely used in clinical settings. Despite good surgical outcomes using sevoflurane, patients frequently develop postoperative cognitive dysfunction (POCD).
Wenfeng Gao, Wenji Xie, Wenqin Xie, Changcheng Jiang, Zhenming Kang, Naizhen Liu   +5 more
doaj   +2 more sources

Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway

Chinese Journal of Physiology, 2023
Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs).
Minmin Cai, Xiang Gao, Shenghui Yu
doaj   +1 more source

Biphasic Memory Impairment and Recovery After Sevoflurane Exposure Are Associated With Time-Dependent Hippocampal α5-GABAAR Remodeling. [PDF]

CNS Neurosci Ther
Our study reveals that the reversible changes in memory impairment and recovery following sevoflurane with dynamic changes of expression and distribution of α5‐GABAAR. Memory impairment is associated with the upregulation of α5‐GABAAR expression and postsynaptic distribution on day 2 after sevoflurane exposure.
Wang S, Chen L, Wang S, Zhang C, Zhang M, Wang Z, Dong J, Liu Q, Dong Z, Wang X, Dong Y, Luo Y, Wang Y, Yin Y.   +13 more
europepmc   +2 more sources

ERα Agonist Protects Aged Female Mice From Sevoflurane Neurotoxicity via PTEN Nuclear Translocation. [PDF]

CNS Neurosci Ther
Repeated sevoflurane exposure induces PTEN nuclear mislocalization, synaptic plasticity impairments, and cognitive deficits in aged female mice, whereas activation of the estrogen receptor α suppresses PTEN nuclear mislocalization, thereby ameliorating synaptic plasticity and cognitive dysfunction.
Zhang X, Lei Y, Gong B, Xu Y, Li D, Yu Y, Li F, Luo J.   +7 more
europepmc   +2 more sources

Sevoflurane Preconditioning Increases Stress Resistance via IMB-2/DAF-16 in Caenorhabditis Elegans

Dose-Response, 2022
Sevoflurane preconditioning has been proved to possess therapeutic effects on stress. However, the mechanism by which sevoflurane preconditioning protects against stress remains unclear.
Yue Cao MMed, Yongchen Cui MMed, Junling Liao MMed, Chente Gao MMed, Zhe Zhao MD, Junfeng Zhang MD   +5 more
doaj   +1 more source

Sevoflurane [PDF]

F1000Research, 2015
Sevoflurane has been available for clinical practice for about 20 years. Nowadays, its pharmacodynamic and pharmacokinetic properties together with its absence of major adverse side effects on the different organ systems have made this drug accepted worldwide as a safe and reliable anesthetic agent for clinical practice in various settings.
Stefan De Hert, Anneliese Moerman
openaire   +2 more sources

Inhibition of Adult Hippocampal Neurogenesis Plays a Role in Sevoflurane-Induced Cognitive Impairment in Aged Mice Through Brain-Derived Neurotrophic Factor/Tyrosine Receptor Kinase B and Neurotrophin-3/Tropomyosin Receptor Kinase C Pathways

Frontiers in Aging Neuroscience, 2022
Sevoflurane anesthesia induces cognitive impairment, which may lead to perioperative neurocognitive disorders (PND). However, the factors and molecular mechanism underlying this impairment remains unclear.
Lichi Xu, Yanjing Guo, Yanjing Guo, Gongming Wang, Gongming Wang, Guoqing Sun, Guoqing Sun, Wei Sun, Wei Sun, Jingjing Li, Xinlei Li, Jiangnan Wu, Mengyuan Zhang, Mengyuan Zhang   +13 more
doaj   +1 more source

NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2

Open Life Sciences, 2023
Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been
Zhong Yuanping, Zhao Pengcheng, Zhang Chao, Wu Zhenyu, Fang Xu, Zhu Zhaoqiong   +5 more
doaj   +1 more source

Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus. [PDF]

PLoS ONE, 2013
BACKGROUND: Our previous studies revealed that application of the inhalation anesthetic, sevoflurane, reversibly repressed the expression of Per2 in the mouse suprachiasmatic nucleus (SCN). We aimed to examine whether sevoflurane directly affects the SCN.
Megumi Anzai, Norio Iijima, Shimpei Higo, Ken Takumi, Izumi Matsuo, Keisuke Mori, Yumiko Ohe, Kana Kadota, Toshio Akimoto, Atsuhiro Sakamoto, Hitoshi Ozawa   +10 more
doaj   +1 more source