Results 51 to 60 of about 37,501 (234)

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Sevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion

, 2014
Background: Transplants cause ischemia-reperfusion (IR) injury that can affect distant organs. Liver is particularly sensitive to IR injury. The present randomized experimental study was designed to investigate a possible protective effect of sevoflurane
Isea, Jesús, Cusati, Gabriel, Erquicia, Iñaki, Cusati, G, Paredes Royano, Sergio Damián, García, C, Simón Adiego, Carlos María, Isea, J, Garutti Martínez, Ignacio, Rancán, Lisa, Vara Ameigeiras, Elena María, Huerta Martínez, Luis Javier, Erquicia, I, García Martín, M. Cruz   +13 more
core   +1 more source

Speed of Recovery and Side-effect Profile of Sevoflurane Sedation Compared with Midazolam

, 2001
Background Sedation for surgical procedures performed with regional or local anesthesia has usually been achieved with intravenous medications, whereas the use of volatile anesthetics has been limited.
Ghoneim, Mohamed M., Epstein, Richard H., Binstock, Wendy B., the Sevoflurane Sedation Study Group, Epstein, Richard, Kharasch, Evan D., Groudine, Scott B., Ibrahim, Andra E., Ebert, Thomas J., Philip, Beverly K.   +9 more
core   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

Comparison of Different Neostigmine Doses for Reversal of Cisatracurium‐Induced Neuromuscular Block in Children Under Total Intravenous Anesthesia: A Randomized Controlled Trial

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neostigmine is widely used to reverse nondepolarizing neuromuscular blockade in children, but the optimal dose under total intravenous anesthesia is uncertain. Aims The primary aim was to compare the time to full neuromuscular recovery (TOF ratio of 1.0) following administration of neostigmine at doses of 0, 10, 20, and 30 μg/kg in ...
Antonio J. M. M. Neto, Guilherme L. Benette, Letícia C. Siqueira, Marian M. Santos, Marco A. P. Costa, Rodrigo L. Alves, Eduardo T. Moro, Norma S. P. Módolo   +7 more
wiley   +1 more source

Neuromuscular Monitoring of Rocuronium 0.6 mg/kg in Children Aged 3–24 Months With Electromyography and Acceleromyography: An Observational Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Objective neuromuscular monitoring is essential to prevent residual neuromuscular block in patients receiving neuromuscular blocking agents. However, the small size of pediatric hands and the lack of appropriately sized neuromuscular equipment have made quantitative neuromuscular monitoring at the ulnar nerve (UN) difficult. In such
Sarah Sofie Wadland, Karl Peter Damgård Madsen, Mikkel Helmuth Jensen, Magnus Fuhr Hovind, Morten Sonne, Morten Bøttger, Arash Afshari, Frederik Mondrup, Matias Vested   +8 more
wiley   +1 more source

Sevoflurane Therapy for Severe Refractory Bronchospasm in Children

, 2016
Este artículo presenta una serie de casos clínicos que exploran el uso del sevoflurano en el tratamiento del broncoespasmo severo en niños. Aunque se trata de un estudio con limitaciones propias de este tipo de diseño, los resultados sugieren que el ...
Mencía Bartolomé, Santiago, Palacios, Alba, Alba Palacios, Blanca Toledo, Jaime Cruz, Jesus Lopez-Herce, Ana M. Llorente, Cruz, Jaime, Toledo, Blanca, Ordoñez, Olga, Marta Olmedilla, López-Herce Cid, Jesús, Santiago Mencía, Olmedilla, Marta, Llorente, Ana, Olga Ordóñez   +15 more
core   +1 more source

Association of Preoperative Inflammatory Markers With Preoperative Anxiety and Emergence Agitation in Children

Pediatric Anesthesia, EarlyView.
ABSTRACT Introduction Emergence agitation (EA) is a postoperative neurobehavioral complication characterized by a transient disturbance in cognition and perception following anesthesia. Neuroinflammation is thought to play a central role in its pathophysiology.
Nezahat Merve Ata Soylu, Zehra Hatipoglu, Ersel Gulec, Mediha Turktan, Nurefsan Sadıkoglu, Yusuf Kemal Arslan, Dilek Ozcengiz   +6 more
wiley   +1 more source

Investigation of Genotoxic Effect of Desflurane and Sevoflurane on Periferic Lymphocyte with Comet Assay Method

, 2016
Aim: There are several clinical and cytogenetic studies that anesthetics cause choromosomal changes. We report data on the possible genotoxic properties of two inhalational anaesthetics, sevoflurane and desflurane in lymphocytes of children evaluated for
Kendigelen, Pınar, Tütüncü, Ayşe Çiğdem, Çakmakkaya, Serpil, Serpil Çakmakkaya, Güner Kaya, Yeşim Işıkçı, IŞIKÇI, Yeşim, Kaya, Güner, Ayşe Çiğdem Tütüncü, Fatiş Altındaş, Altındaş, Fatiş, Pınar Kendigelen   +11 more
core   +1 more source