Results 71 to 80 of about 60,245 (274)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Therapeutic effects of intravenous administration of bone marrow stromal cells on sevoflurane-induced neuronal apoptosis and neuroinflammation in neonatal rats [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundSevoflurane exposure during the early postnatal period causes neuroinflammation and neuronal apoptosis in rodents. Bone marrow stromal cells (BMSCs) have been shown to protect and repair the damaged central nervous system, for example in ...
ZhongLiang Sun, Maiko Satomoto, Koshi Makita   +2 more
doaj   +1 more source

Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation

Brain Sciences, 2023
Postoperative cognitive dysfunction (POCD), an important postoperative neurological complication, is very common and has an elevated incidence in elderly patients.
Junjie Liang, Shanshan Han, Chao Ye, Haimeng Zhu, Jiajun Wu, Yunjuan Nie, Gaoshang Chai, Peng Zhao, Dengxin Zhang   +8 more
doaj   +1 more source

Effects of early postnatal sevoflurane exposure on oligodendrocyte maturation and myelination in cerebral white matter of the rat.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
General anaesthesia may impose significant neurocognitive risks on the developing brain. As brain injury in preterm neonates has a particular predilection for cerebral white matter, we aimed to evaluate the effects of sevoflurane on oligodendrocyte ...
Zi-yi Wu, H. Xue, Qiushi Gao, P. Zhao
semanticscholar   +1 more source

Detecting high‐frequency oscillations in real time during epilepsy surgery with neuromorphic hardware validated to predict postoperative seizure outcome

Epilepsia, EarlyView.
Abstract Objective High‐frequency oscillations (HFOs; 250–500 Hz) in electrocorticography (ECoG) are promising biomarkers for delineating the epileptogenic zone during epilepsy surgery. Accurate, intraoperative real‐time detection of HFOs may guide surgical resection to improve seizure outcome.
Jeroen Teurlings, Filippo Costa, Maeike Zijlmans, Maryse A. van ‘t Klooster, Giacomo Indiveri, Niklaus Krayenbühl, Murezi Capaul, Debora Ledergerber, Georgia Ramantani, Johannes Sarnthein   +9 more
wiley   +1 more source

The Effects of Propofol-Sevoflurane, Midazolam-Sevoflurane and Medetomidine-Ketamine-Sevoflurane Anesthetic Combinations on Intraocular Pressure in Rabbits [PDF]

, 2020
Intraocular pressure (IOP) is dependent on equilibrium between the rate of formation and outflow humor aqueous in the eye. Determination of IOP is one of the most important points and a very useful parameter in ophthalmic surgery.
Erol, Muharrem, EROL, HANİFİ, ATALAN, GÜLTEKİN, YÖNEZ, MUHAMMED KAAN, Ceylan, Cengiz   +4 more
core   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts

Frontiers in Physiology, 2022
Inhalation anesthetics isoflurane and sevoflurane have been widely used in clinical practice for anesthesia. However, the molecular mechanisms underlying the faster recovery from sevoflurane anesthesia than isoflurane anesthesia remain largely ...
Zongyuan Ma, Jialin C. Zheng, Tianzuo Li, Zhongcong Xie, Le Kang   +4 more
doaj   +1 more source

Dexmedetomidine and clonidine attenuate sevoflurane-induced Tau phosphorylation and cognitive impairment in young mice via alpha-2 adrenergic receptor

Anesthesia and Analgesia, 2020
Background: Anesthetic sevoflurane induces Tau phosphorylation and cognitive impairment in young mice. The underlying mechanism and the targeted interventions remain largely unexplored.
Mingyang Sun, Yuanlin Dong, Mengzhu Li, Yiying Zhang, Feng Liang, Jiaqiang Zhang, S. Soriano, Zhongcong Xie   +7 more
semanticscholar   +1 more source

Single‐stage orthognathic correction of campylorrhinus lateralis in foals using transection and fixation: Surgical description and outcome of four horses

Equine Veterinary Journal, EarlyView.
Abstract Background Campylorrhinus lateralis (‘wry nose’) is a rare congenital maxillofacial deformity of foals resulting in compromise of the airway and severe class 4 malocclusion. Various surgical techniques to correct the deformity have been described, but contemporary data on single‐stage transection and fixation, including use of a rib graft, and
Helio Vasco, Jim Schumacher, Jack Easley
wiley   +1 more source