Results 171 to 180 of about 616,628 (329)

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan   +5 more
wiley   +1 more source

Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This represents the first serial hepatocyte transplantation pig model designed to investigate the massive hepatocyte proliferation in vivo. Leveraging this novel model, we achieved serial hepatocyte transplantation and regeneration in a porcine model, where the transplanted hepatocytes effectively repopulated the livers of two‐generation model pigs in ...
Zhiqiang Han   +10 more
wiley   +1 more source

Diosgenin ameliorates silica‐induced tuberculosis in rats

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Silicosis increases susceptibility to tuberculosis due to impaired macrophage function and oxidative stress. This study demonstrates that diosgenin, a steroidal saponin, significantly inhibits Mycobacterium smegmatis (IC₅₀ = 0.006 μg/mL), reduces lung fibrosis, and restores antioxidant enzyme levels (↑SOD, ↑CAT, ↓MDA) in silica‐exposed rats ...
Williams Asamoah Adu   +5 more
wiley   +1 more source

Catatonia induced by nitrous oxide anesthesia in a healthy adolescent: A case report. [PDF]

open access: yesPCN Rep
Kobayashi KS   +5 more
europepmc   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage   +4 more
wiley   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong   +9 more
wiley   +1 more source

The mechanisms of carbon monoxide production by inhalational agents [PDF]

open access: yes, 2006
COPPENS, MARC   +4 more
core   +2 more sources

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