Results 221 to 230 of about 73,729 (291)

Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low‐Tech Injury and Instillation Methods

open access: yesThe Laryngoscope, EarlyView.
Improving experimental mouse vocal fold injury and instillation approaches is necessary to advance preclinical models of laryngeal disease. We have successfully repurposed low‐tech, quick, and reliable injury and instillation methods established in respiratory research. Using these methods, we show that murine vocal fold epithelium is inherently highly
Renee E. King   +2 more
wiley   +1 more source

Increasing Infusion Times of Hyperpolarized [1‐13C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo‐Steady State Metabolism

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate whether varying delivery times of hyperpolarized [1‐13C]pyruvate, enabled by the increased apparent T1 dissolved in deuterium oxide (D2O), affects the observed kinetics of glycolytic brain metabolism in vivo. Methods Eighteen healthy mice were injected with 300 μL of hyperpolarized [1‐13C]pyruvate dissolved in D2O at ...
Paola Porcari   +5 more
wiley   +1 more source

Multiparametric MRI to Predict Response to Irreversible Electroporation Plus Anti‐PD‐1 Immunotherapy in Pancreatic Ductal Adenocarcinoma

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate contrast‐enhanced T1‐weighted MRI and diffusion‐weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti‐PD‐1 immunotherapy. Methods Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice.
Qizhen Cao   +9 more
wiley   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

open access: yesNeuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai   +3 more
wiley   +1 more source

Spinal cord transection repair occurs when Nestin+ cells differentiate into neurons within a taxol‐collagen‐enhanced microenvironment in mice

open access: yesNeuroprotection, EarlyView.
We utilized Nestin‐CreER:tdTomato transgenic mice to directly illustrate that taxol could induce the differentiation of neural stem cells (NSCs) into neurons. This process promoted the formation of a nerve bridge connecting the two ends of the injury, ultimately resulting in the functional improvement of spinal cord injury (SCI) animals.
Caixia Fan   +6 more
wiley   +1 more source

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