Results 151 to 160 of about 1,112,203 (353)
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao +13 more
wiley +1 more source
The site of emetic action of veratrum derivatives. [PDF]
, 1951 Thesis (M.A.)--Boston ...
Swiss, Edward D
core +1 more source
[Intravenous regional anesthesia].
Ugeskrift for laeger, 2003 Intravenous regional anesthesia (IVRA) is established by administration of local anesthetics in a vein on the extremity, isolated from the rest of the body by a pneumatic tourniquet. The local anesthetics act directly on the small nerve endings and on bigger nerves in the cubital fossa.
Fynboe, MS +3 more
openaire +2 more sources
Advanced Science, EarlyView.A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du +9 more
wiley +1 more source
Advanced Science, EarlyView.The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang +7 more
wiley +1 more source
In vivo multi-parametric imaging of metastatic and non-metastatic breast cancer [PDF]
, 2017 A current issue in cancer therapy is the characterization of metastatic tumors, which can increase ease of treatment and patient trials. We present an in vivo study of metastatic (4T1) and non-metastatic (4T1-TWIST KO) breast tumor sister cell lines to ...
Rasul, Raisa B
core +2 more sources
Advanced Science, EarlyView.These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin +10 more
wiley +1 more source
Advanced Science, EarlyView.EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu +7 more
wiley +1 more source
Intravenous paraldehyde anesthesia
Kazan medical journal, 1936 In psychiatric hospitals, minor surgery puts the surgeon in a certain difficulty, when local or general inhalation anesthesia is practically impossible.
openaire +2 more sources