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The thermodynamics of general and local anesthesia [PDF]

open access: yesBiophys. J. 2014, 106: 2143-2156, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare   +2 more
arxiv   +9 more sources

Local Anesthesia [PDF]

open access: yes, 2018
Local anesthesia is a routine procedure in dermatological practice. This chapter deals with the basic principles of pharmacology and pharmacodynamics related to the most commonly used anesthetics in dermatology as well as its side effects, the most ...
de Abreu Camargo, Caio Lamunier
core   +4 more sources

Radial Nerve Supracondylar Block Versus Fracture Hematoma Block. Comparison of Their Efficacy in Cases of Fractures of the Distal Third of the Radius [PDF]

open access: yesRevista Brasileira de Ortopedia, 2023
Objective The present study compares the analgesic efficacy of two techniques to perform non-surgical reduction: fracture hematoma block and radial nerve supracondylar block.
Guilherme de Albuquerque Souza Maia   +5 more
doaj   +1 more source

Effect of thermo mechanical stimulation during local anesthesia in pediatric dentistry: a pilot randomized clinical trial

open access: yesRevista da Faculdade de Odontologia de Porto Alegre, 2023
Aim: To evaluate the effectiveness of a thermo mechanical stimulation device (Buzzy®) in relation to pain, fear and anxiety during local anesthesia in children.
Fernanda Vieira Almeida   +5 more
doaj   +1 more source

Prolonged exposure of neonatal mice to sevoflurane leads to hyper-ramification in microglia, reduced contacts between microglia and synapses, and defects in adult behavior

open access: yesFrontiers in Neurology, 2023
BackgroundProlonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear.
Hong Li   +13 more
doaj   +1 more source

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders

open access: yesNeural Plasticity, 2021
Two-pore-domain potassium (K2P) channels are widespread in the nervous system and play a critical role in maintaining membrane potential in neurons and glia.
Yuncheng Luo   +3 more
doaj   +1 more source

Brachial Plexus Nerve Trunk Segmentation Using Deep Learning: A Comparative Study with Doctors' Manual Segmentation [PDF]

open access: yes[J]. Ultrasound in Medicine & Biology, 2024, 50(3): 374-383, 2022
Ultrasound-guided nerve block anesthesia (UGNB) is a high-tech visual nerve block anesthesia method that can observe the target nerve and its surrounding structures, the puncture needle's advancement, and local anesthetics spread in real-time. The key in UGNB is nerve identification.
arxiv   +1 more source

Surgical treatment of varicose vein using the tumescent technique of local anesthesia [PDF]

open access: yesVojnosanitetski Pregled, 2011
Background/Aim. Tumescent local anesthesia (TLA) is a technique for local and regional anesthesia of the skin and the subcutaneous tissue, using infiltration of large amounts of a diluted solution of local anesthetic. This technique is applied in plastic
Bjelanović Zoran   +4 more
doaj   +1 more source

The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature [PDF]

open access: yes, 2017
Background: Yearly approximately 4500 umbilical hernias are repaired in The Netherlands, mostly under general anesthesia. The use of local anesthesia has shown several advantages in groin hernia surgery.
Jairam, A.P. (An)   +4 more
core   +8 more sources

Empagliflozin protects against renal ischemia/reperfusion injury in mice

open access: yesScientific Reports, 2022
Renal ischemia/reperfusion (I/R) can induce acute kidney injury. Empagliflozin is a newly developed inhibitor of sodium-glucose cotransporter-2 (SGLT2) approved as an antidiabetic medication for patients with type 2 diabetes mellitus.
Qifeng Wang   +6 more
doaj   +1 more source

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