Results 171 to 180 of about 5,124,662 (283)

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

open access: yesAdvanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo   +16 more
wiley   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

open access: yesAdvanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo   +10 more
wiley   +1 more source

Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation

open access: yesAdvanced Science, EarlyView.
Exogenous alternating current fields are explored and interact with cerebral cortex slow waves in vitro and in silico. Varying frequency and amplitude of sine waves result in distinct network dynamics, from phase‐locking and entrainment to desynchronization. These responses occupy specific regions within the parameter space.
Joana Covelo   +4 more
wiley   +1 more source

Prospective study of the efficacy of PCNL under local anesthesia based on the ERAS concept. [PDF]

open access: yesFront Surg
Liu Z   +7 more
europepmc   +1 more source

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

open access: yesAdvanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana   +10 more
wiley   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

open access: yesAdvanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi   +10 more
wiley   +1 more source

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