Results 21 to 30 of about 650,842 (216)

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Frontiers in Neural Circuits, 2023
BackgroundHow volatile anesthetics work remains poorly understood. Modulations of synaptic neurotransmission are the direct cellular mechanisms of volatile anesthetics in the central nervous system.
Jingxuan Qiu, Jingxuan Qiu, Yaoxin Yang, Yaoxin Yang, Jin Liu, Wenling Zhao, Qian Li, Qian Li, Tao Zhu, Peng Liang, Cheng Zhou   +10 more
doaj   +1 more source

Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets

Molecules, 2022
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is not functionally expressed in the recombinant system.
Xueming Fan, Yongzhi Lu, Guizhi Du, Jin Liu   +3 more
doaj   +1 more source

Analysis of direct costs of anesthesia-related materials between spinal and venous anesthesia with propofol associated with local perianal block in hemorrhoidectomy

Journal of Coloproctology, 2011
There is no consensus on the ideal anesthesia for hemorrhoidectomy in ambulatory facilities. Spinal anesthesia and venous propofol associated with local perianal block (combined anesthesia) are frequently used, and their direct costs may be crucial for ...
Paulo Gustavo Kotze, Ilario Froehner Junior, Cristiano Denoni Freitas, Fábio Diniz, Álvaro Steckert-Filho   +4 more
doaj   +1 more source

Ultrasound-Guided WALANT Technique in Carpal Tunnel Decompression Surgery* [PDF]

Revista Brasileira de Ortopedia, 2023
Carpal tunnel syndrome (CTS) is the most common compressive neuropathy in the human body. Its symptoms result from compression of the median nerve in the carpus.
Sandro B. Moreira, Danilo C. Chagas, Caetano T. Yamashita   +2 more
doaj   +1 more source

History of anesthesia usage in dentistry [PDF]

Stomatološki glasnik Srbije, 2005
Since prehistoric times, man has sought ways to lessen pain. With varying degrees of success he has utilized: opium, nerve compresses, cold, hypnosis, etc.
Koković Vladimir
doaj   +1 more source

Single puncture combined lumbar erector spinae plane and quadratus lumborum block (SEQ block) in acetabular fracture surgeries: randomized clinical trial [PDF]

Anesthesia and Pain Medicine, 2023
Background Acetabular fracture surgery can cause severe postoperative pain. A combined lumbar erector spinae plane block and paraspinous sagittal shift quadratus lumborum block may augment analgesia. Methods Fifty two patients undergoing posterior column
Aly Mahmoud Moustafa Ahmed, Moustafa Abdelaziz Moustafa, Ahmad Samir Alabd   +2 more
doaj   +1 more source

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear.
Mengchan Su, Mengchan Su, Yidan Tang, Yidan Tang, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source

Pharmacokinetic/Pharmacodynamic Anesthesia Model Incorporating psi-Caputo Fractional Derivatives [PDF]

Computers in Biology and Medicine 167 (2023), Art. 107679, 9 pp, 2023
We present a novel Pharmacokinetic/Pharmacodynamic (PK/PD) model for the induction phase of anesthesia, incorporating the $\psi$-Caputo fractional derivative. By employing the Picard iterative process, we derive a solution for a nonhomogeneous $\psi$-Caputo fractional system to characterize the dynamical behavior of the drugs distribution within a ...
arxiv   +1 more source

Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs

Frontiers in Pharmacology, 2022
Among the advancements in drug structural modifications, the increased focus on drug metabolic and pharmacokinetic properties in the anesthetic drug design process has led to significant developments.
Chaoyi Deng, Chaoyi Deng, Jin Liu, Jin Liu, Wensheng Zhang, Wensheng Zhang   +5 more
doaj   +1 more source

Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide

Frontiers in Pharmacology, 2022
Although local anesthetics (LAs) such as lidocaine have been traditionally used for pain relief, their antitumor activity has attracted more and more attentions in recent years.
Yang Yang, Yang Yang, Jiaxiao Sun, Fei Peng, Fei Peng, Haibei Liu, Haibei Liu, Guoyan Zhao, Guoyan Zhao, Junjie Chen, Wensheng Zhang, Wensheng Zhang, Feng Qiu, Feng Qiu   +13 more
doaj   +1 more source