Results 61 to 70 of about 15,072 (282)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Effect of dural puncture epidural combined with programmed intermittent epidural bolus on labor analgesia in patients with gestational hypertension: a randomized controlled clinical trial

Frontiers in Medicine
BackgroundHypertensive disorders of pregnancy affect 5–10% of pregnancies and require the maintenance of hemodynamic stability while providing effective labor analgesia.
Binghui Zhang, Hongyang Zhang, Yuan Wu, Guofang Li, Shuxiang Liu, Kai Zhao   +5 more
doaj   +1 more source

Charlotte Seymour Yapp [PDF]

, 2013
Charlotte Seymour Yapp was born in October 1879, in Ardwick, Manchester, to Moses Yapp, a railway guard, and his wife, Sophia (nee Seymour), a seamstress.
Chatterton, Claire, Wade, Lesley
core  

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Pain relief effects of ropivacaine for perineal pain during vaginal delivery under epidural labor analgesia: a double-blind randomized controlled trial

Di-san junyi daxue xuebao, 2019
Objectives To compare the effects of ropivacaine versus lidocaine infiltration on the pain relief for perineal pain of puerpera undergoing vaginal delivery. Methods This is a prospective, randomized, double-blind study.
ZHU Yuan, XIONG Ya, LI Hongyu
doaj   +1 more source

“An unsuitable job for a woman? Gender and mental health nursing.” [PDF]

, 2013
On the evening of Wednesday 12th May 1920 a demonstration took place in the city of Wakefield, in West Yorkshire. According to the ‘Wakefield Express,’ a large procession with banners flying, and with the city’s band at its head, marched through the ...
Chatterton, Claire
core  

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Anesthetic Considerations for Labor and Delivery in Cancer Patients: A Review [PDF]

Middle East Journal of Cancer
Background: The trend of postponing childbirth has led to an increased incidence of cancer diagnoses during pregnancy, including breast cancer, cervical cancer, lymphoma, ovarian cancer, and melanoma.
Fatemeh Shafiei
doaj  

Comparison of the Effectiveness of Ultrasound-guided Transversalis Fascia Plane Block (TFPB) and Transversus Abdominis Plane Block (TAPB) on Postoperative Pain in Caesarean Section: A Prospective Randomized Study

Bagcilar Medical Bulletin, 2023
Objective:Postoperative peripheral trunk blocks are used for multimodal analgesia in caesarean sections. This trial was planned to compare the efficacy of transversalis fascia plane block (TFPB) and transversus abdominis plane block (TAPB) in ...
Duygu Akyol, Necmiye Ay, Funda Gümüş Özcan, İbrahim Polat   +3 more
doaj   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source