Results 111 to 120 of about 66,601 (198)

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography

Clinical Anatomy, EarlyView.
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes, Valentina Pizzuti, Maria A. Wright, Kane P. J. Colston, Thomas Santarius, Susan Jones   +5 more
wiley   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

Chemistry &Biodiversity, EarlyView.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad, El‐Mahdi Ourhzif, Salha Hamri, Hafid Abderrafia, Mostafa Khouili, Maria Dolors Pujol   +5 more
wiley   +1 more source

Enhanced Drug Effect With Cutting Balloon Followed by Drug Coated Balloon in a Rabbit Model

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Drug‐coated balloon (DCB) are effective treatment options for patients with coronary artery disease and using of scoring or cutting balloon before the DCB usage were recommended. However, the effectiveness of lesion preparation with cutting balloons (CB) followed by DCB (CB + DCB) has not been evaluated before.
Manabu Shiozaki, Sho Torii, Yu Sato, Kazuki Aihara, Yuki Matsumoto, Norihito Nakamura, Daiki Suzuki, Ayako Yoshikawa, Yuji Ikari, Gaku Nakazawa   +9 more
wiley   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source

Calpastatin, a calpain specific inhibitor, reduce seizures in a mouse model of temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Epilepsy is a chronic condition characterized by unpredictable and recurrent spontaneous seizures. In a previous study, we reported that pharmacological inhibition of calpain prevented epileptogenesis in the rat pilocarpine model. In this study, we demonstrate that transgenic overexpression of calpastatin, the endogenous inhibitor of calpain ...
Philip M. Lam, Mala V. Rao, Ralph A. Nixon, Marco I. González   +3 more
wiley   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, EarlyView.
Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide

Glia, EarlyView.
Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel peptide that promotes OL myelin formation. ABSTRACT In the central nervous system, oligodendrocytes (OLs) form myelin sheaths that accomplish the efficient ...
Binri Sasaki, Momo Oishi, Tomoka Aoki, Mai Hyodo, Chinami Onchi, Nanako Yamada, Hitomi Misawa, Momona Yamada, Chikako Hayashi, Kiyotoshi Sekiguchi, Keisuke Hamada, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu, Nobuharu Suzuki   +14 more
wiley   +1 more source