Results 31 to 40 of about 172,127 (305)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Regional Anesthesia for Hip Fracture Surgery in Older Adults: A Retrospective Comparison of Outcomes Using ACS NSQIP Data

Geriatric Orthopaedic Surgery & Rehabilitation
Introduction Surgical fixation of hip fractures in older adults is associated with significant morbidity and mortality. We investigated whether regional anesthesia, which excluded epidural, spinal, or combined epidural-spinal, was associated with lower ...
Arissa M. Torrie MD, MHS, Gerard P. Slobogean MD, MPH, Rachel Johnson MD, Ron E. Samet MD, Samuel M. Galvagno DO, PhD, Robert V. O’Toole MD, Nathan N. O’Hara PhD, MHA   +6 more
doaj   +1 more source

Efficiency of spinal anesthesia versus general anesthesia for lumbar spinal surgery: a retrospective analysis of 544 patients. [PDF]

, 2017
BACKGROUND: Previous studies have shown varying results in selected outcomes when directly comparing spinal anesthesia to general in lumbar surgery. Some studies have shown reduced surgical time, postoperative pain, time in the postanesthesia care unit ...
Attiah, Mark A., Kallan, Michael J., Koenigsberg, Rebecca, Kofke, W. Andrew, Kositratna, Guy, Marcotte, Paul J., Pierce, John T., Syre, Peter, Welch, William C., Wyler, MD, David   +9 more
core   +1 more source

Oral transmucosal fentanyl [PDF]

, 1998
None ...
D. Prosser, Friesen, M. Allman, P. Grassby, Streisand   +4 more
core   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

MONOLATERAL SPINAL ANAESTHESIA IN CHILDREN

Travmatologiâ i Ortopediâ Rossii, 2016
Monolateral spinal anaesthesia as a component of general anaesthesia was compared to the spinal anaesthesia as a component of general anaesthesia for the unilateral low extremity orthopedic surgery in children.
A. S. Kozyrev, G. E. Ulrikh, D. V. Zabolotsky, A. G. Kulev, E. G. Kachalova, S. V. Vissarionov, V. V. Murashko   +6 more
doaj   +1 more source

Role of Prednisone and 25‐Hydroxyvitamin D on Bone Mineral Density and Osteoporosis in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi, Andrea Fava, Daniel W. Goldman, Laurence S. Magder, Michelle Petri   +4 more
wiley   +1 more source

A successful combined spinal-epidural anesthesia for cesarean section in a patient with neurofibromatosis type 1-associated dural ectasia

JA Clinical Reports
Background Dural ectasia is a common manifestation of neurofibromatosis type 1. Although there have been reports of unsuccessful spinal anesthesia due to dual ectasia in Marfan syndrome, reports describing similar unsuccessful spinal anesthesia in ...
Hitomi Taka, Nobuyoshi Kusama, Minami Sakamoto, Nobuko Sasano, Motoshi Tanaka   +4 more
doaj   +1 more source

Benefits of using intrathecal buprenorphine [PDF]

, 2014
Background: General anesthesia draws attention to the most commonly used modalities for post cesarean delivery pain relief in systemic administration of opioids, while the administration of small dose of intrathecal opioid during spinal anesthesia can be
Alijanpour, E., Jabbari, A., Rabiee, S.M., Rostami, S.   +3 more
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