Results 91 to 100 of about 1,057,408 (367)

Anesthesia and Surgery Impair Blood–Brain Barrier and Cognitive Function in Mice

Frontiers in Immunology, 2017
Blood–brain barrier (BBB) dysfunction, e.g., increase in BBB permeability, has been reported to contribute to cognitive impairment. However, the effects of anesthesia and surgery on BBB permeability, the underlying mechanisms, and associated cognitive ...
Siming Yang, C. Gu, E. Mandeville, Yuanlin Dong, E. Esposito, Yiying Zhang, Guang Yang, Yuan Shen, Xiaobing Fu, E. Lo, Zhongcong Xie   +10 more
semanticscholar   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia [PDF]

arXiv, 2021
Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level, its effects on neural circuits and overall cortical functioning, which eventually lead to unconsciousness, are ...
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Maternal Satisfaction and Associated Factors with Postcesarean Section Pain Management: A Cross-Sectional Study

Anesthesiology Research and Practice
Background. Maternal satisfaction with pain management after cesarean delivery serves as an indicator of the quality of care. Assessing the level of satisfaction with postcesarean delivery pain management is paramount for both the mother and the ...
Biruk Adie Admass, Fikadu Tadesse Diress, Demeke Yilkal Fentie, Nigussie Simeneh Endalew   +3 more
doaj   +1 more source

The impact of intraoperative and postoperative fluid balance on complications for transthoracic esophagectomy: a retrospective analysis

BMC Research Notes, 2023
Objective Transthoracic esophagectomy is associated with significant morbidity and mortality. Therefore, it is imperative to optimize perioperative management and minimize complications.
Vered Buchholz, Riley Hazard, Zoe Yin, Nghiep Tran, Sui Wah Sean Yip, Peter Le, Benjamin Kioussis, Jake Hinton, David S Liu, Dong-Kyu Lee, Laurence Weinberg   +10 more
doaj   +1 more source

Constructing a control-ready model of EEG signal during general anesthesia in humans [PDF]

arXiv, 2019
Significant effort toward the automation of general anesthesia has been made in the past decade. One open challenge is in the development of control-ready patient models for closed-loop anesthesia delivery. Standard depth-of-anesthesia tracking does not readily capture inter-individual differences in response to anesthetics, especially those due to age,
arxiv  

Comparison between general, spinal, epidural, and combined spinal-epidural anesthesia for cesarean delivery: a network meta-analysis.

International journal of obstetric anesthesia, 2019
BACKGROUND This study is a network meta-analysis to compare maternal and fetal outcomes associated with four different anesthetic techniques for cesarean delivery. METHODS An arm-based, random-effects frequentist network meta-analysis was performed.
W. Kim, M. Hur, S. K. Park, S. Yoo, T. Lim, H. Yoon, Jin-Tae Kim, J. Bahk   +7 more
semanticscholar   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source