Results 71 to 80 of about 1,590,302 (412)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficiency of spinal anesthesia versus general anesthesia for lumbar spinal surgery: a retrospective analysis of 544 patients. [PDF]

, 2017
BACKGROUND: Previous studies have shown varying results in selected outcomes when directly comparing spinal anesthesia to general in lumbar surgery. Some studies have shown reduced surgical time, postoperative pain, time in the postanesthesia care unit ...
Attiah, Mark A., Kallan, Michael J., Koenigsberg, Rebecca, Kofke, W. Andrew, Kositratna, Guy, Marcotte, Paul J., Pierce, John T., Syre, Peter, Welch, William C., Wyler, MD, David   +9 more
core   +1 more source

Burnout in cardiac anesthesiologists. results from a national survey in italy [PDF]

, 2018
Objective: There is increasing burnout incidence among medical disciplines, and physicians working in emergency settings seem at higher risk. Cardiac anesthesiology is a stressful anesthesiology subspecialty dealing with high-risk patients.
Arcadipane, Antonio, Bignami, Elena, Blangetti, Ilaria, Cattaneo, Sergio, Gagliardone, Mariapia, Ippolito, Mariachiara, Locatelli, Alessandro, Lorini, Ferdinando L., Noto, Alberto, Palumbo, Gaetano J., Sanfilippo, Filippo, Sangalli, Fabio, Scarlata, Maria, Scolletta, Sabino, Tritapepe, Luigi   +14 more
core   +1 more source

Benefits and Barriers to Increasing Regional Anesthesia in Resource-Limited Settings

Local and Regional Anesthesia, 2020
Safe and accessible surgical and anesthetic care is critically limited for over half of the world’s population, particularly in Sub-Saharan African and Southeast Asian countries.
L. Dohlman, A. Kwikiriza, Odinakachukwu Ehie   +2 more
semanticscholar   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Postoperative malignant hyperthermia confirmed by calcium-induced calcium release rate after breast cancer surgery, in which prompt recognition and immediate dantrolene administration were life-saving: a case report

Journal of Medical Case Reports, 2021
Background Malignant hyperthermia (MH) is a rare genetic disease characterized by the development of very serious symptoms, and hence prompt and appropriate treatment is required. However, postoperative MH is very rare, representing only 1.9% of cases as
Natsumi Miyazaki, Takayuki Kobayashi, Takako Komiya, Toshio Okada, Yusuke Ishida, Hidekimi Fukui, Yukihiko Ogihara, Hiroyuki Uchino   +7 more
doaj   +1 more source

A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]

, 2016
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K., Grant, A., Harrison, P., Kearns, R., Kinsella, J., Macfarlane, A., Puxty, K., Shaw, M.   +7 more
core   +1 more source

Total Intravenous Anesthesia versus Inhalation Anesthesia for Breast Cancer Surgery: A Retrospective Cohort Study

Anesthesiology, 2019
What We Know about This Topic IV anesthesia may impair anticancer immunity less than volatile anesthesia and therefore reduce recurrence risk What This Article Tells Us That Is New In a large propensity-matched retrospective cohort analysis, the authors ...
S. Yoo, Han-Byoel Lee, W. Han, D. Noh, Sun-Kyung Park, W. Kim, Jin-Tae Kim   +6 more
semanticscholar   +1 more source

Exposure to General Anesthesia for Cesarean Delivery and Odds of Severe Postpartum Depression Requiring Hospitalization.

Anesthesia and Analgesia, 2020
BACKGROUND Previous research suggests that, compared with regional anesthesia, general anesthesia is associated with increased odds of postoperative depressive disorders.
J. Guglielminotti, Guohua Li
semanticscholar   +1 more source