Results 271 to 280 of about 198,224 (314)
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Anesthesiology, 1979
Anesthetic toxicity can be strictly defined as a potentially harmful action or effect that is not part of the expected anesthetic or pharmacologic action of the agent. Such a definition would exclude the undesirable effects of an overdose of an anesthetic agent (wherein the expected pharmacologic effects are simply exaggerated) or a recognized expected
John D. Michenfelder +1 more
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Anesthetic toxicity can be strictly defined as a potentially harmful action or effect that is not part of the expected anesthetic or pharmacologic action of the agent. Such a definition would exclude the undesirable effects of an overdose of an anesthetic agent (wherein the expected pharmacologic effects are simply exaggerated) or a recognized expected
John D. Michenfelder +1 more
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The Anesthetic Efficacy of Midazolam in the Enflurane-anesthetized Dog
Anesthesiology, 1987This study determined the anesthetic efficacy of midazolam (MID) in terms of its ability to reduce enflurane MAC (EMAC). Control EMAC was determined by the tail-clamp method in 15 mongrel dogs. Each animal then received at least three incremental infusion rates of MID from among the following: 0.48, 2.4, 9.6, 19.2, 28.8, 48, or 151.2 micrograms.kg-1 ...
Ian M. Schwieger +2 more
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The effect of anesthetic charge on anesthetic-phospholipid interactions
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981Cationic and uncharged forms of a tertiary amine local anesthetic are reported to have different properties and potencies as nerve blocking agents. However, the relative capacities of each form of the local anesthetic to perturb the properties of different model membrane systems is unknown.
Philip S. Low, Stephen R. Davio
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Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain
Anesthesiology, 1993The brain is assumed to be the site of anesthetic action, but anesthetics have effects elsewhere, such as the spinal cord. A preferentially anesthetized goat brain model was used to determine the importance of anesthetic action in the brain.Six goats were anesthetized with isoflurane; after tracheal intubation and insertion of a femoral arterial ...
Kevin Schwartz, Joseph F. Antognini
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Current Opinion in Anaesthesiology, 2001
Intravenous anesthetics continue to be a mainstay in the modern anesthesiologist's armamentarium. In this review the authors will discuss new advancements in the use of propofol, as well as a greater understanding as to its mechanism of action. Further, we will discuss the use of target controlled infusion systems, touch upon the possible benefits of ...
J, Petrie, P, Glass
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Intravenous anesthetics continue to be a mainstay in the modern anesthesiologist's armamentarium. In this review the authors will discuss new advancements in the use of propofol, as well as a greater understanding as to its mechanism of action. Further, we will discuss the use of target controlled infusion systems, touch upon the possible benefits of ...
J, Petrie, P, Glass
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Dermatologic Surgery, 1996
Dermatology is dependent upon the effects of local anesthetics for diagnostic and therapeutic interventions. A working knowledge of the drugs' actions and interactions is necessary for anyone aspiring to optimize the benefits derived from the use of local anesthetic agents.This article reviews nerve physiology, pharmacology, classification of local ...
R A, Skidmore +2 more
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Dermatology is dependent upon the effects of local anesthetics for diagnostic and therapeutic interventions. A working knowledge of the drugs' actions and interactions is necessary for anyone aspiring to optimize the benefits derived from the use of local anesthetic agents.This article reviews nerve physiology, pharmacology, classification of local ...
R A, Skidmore +2 more
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Anesthesiology Clinics of North America, 2002
The action of anesthetics on the nervous system can be understood by considering their possible interactions with neuronal function. Anesthesia may be produced by a change in the balance of inhibitory synapses (notable via GABAa receptors) and excitatory synapses (notably glutamate receptors).
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The action of anesthetics on the nervous system can be understood by considering their possible interactions with neuronal function. Anesthesia may be produced by a change in the balance of inhibitory synapses (notable via GABAa receptors) and excitatory synapses (notably glutamate receptors).
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Disposition of Anesthetic and Anesthetic-Related Agents in Ruminants
Veterinary Clinics of North America: Food Animal Practice, 1986Many factors may influence the actions and fates of anesthetic and anesthetic-related agents in ruminant animals. These considerations need to be taken into account when these drugs are employed clinically. Some of the major principles governing the disposition of CNS-active drugs are reviewed, with special emphasis on the uniqueness of ruminant ...
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Emergency Medicine Clinics of North America, 1992
Emergency physicians often rely on the use of local anesthetic agents to relieve patient discomfort, and research continues in an effort to develop new agents with improved anesthetic qualities. Eventually, a nontoxic, rapidly acting agent may become available that could provide profound anesthesia of long duration when applied topically to intact skin
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Emergency physicians often rely on the use of local anesthetic agents to relieve patient discomfort, and research continues in an effort to develop new agents with improved anesthetic qualities. Eventually, a nontoxic, rapidly acting agent may become available that could provide profound anesthesia of long duration when applied topically to intact skin
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2003
Operations, such as vasectomy and oviduct transfer, are performed on anesthetized animals. It is essential that the experimenter is familiar with this procedure and that the anesthetic has been tested: A lethal dose of anesthetic administered prior to an oviduct transfer is an unfortunate end to a day spent collecting and microinjecting eggs.
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Operations, such as vasectomy and oviduct transfer, are performed on anesthetized animals. It is essential that the experimenter is familiar with this procedure and that the anesthetic has been tested: A lethal dose of anesthetic administered prior to an oviduct transfer is an unfortunate end to a day spent collecting and microinjecting eggs.
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