Results 311 to 320 of about 330,975 (366)

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Pain and Anxiety Levels During Dental Restorations in Primary Molars: INJEX Needleless System vs Traditional Syringe. [PDF]

Med Sci Monit
Maganur PC, Vishwanathaiah S, Jafer MA, Moafa I, Alessa N, Assiry AA, Altowairqi SA, Basheri AAM, Najmi HH, Alhazmi ZA, Maafa SM, Jeevanandan G, Manoharan V.   +12 more
europepmc   +1 more source

Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia

Advanced Science, EarlyView.
Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li, Yehui Wu, Yihan Wang, Yumin Wu, Rong Hu, Si Long, Wenqi Huang, Liming Nie, Zhongxing Wang   +8 more
wiley   +1 more source

Ultrasound-Guided Rectus Sheath Block With Monitored Anesthesia Care for Necrotic Umbilical Hernia Repair in a Patient With Severe Liver Failure and Refractory Ascites: A Case Report. [PDF]

Cureus
Nakazawa K, Ishikawa R, Suzuki T.
europepmc   +1 more source

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

Advanced Science, EarlyView.
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa, Jiali Wang, Mengzhao Xun, Jessica M. Rosenholm, Wuqing Wang, Yilai Shu, Hongbo Zhang   +6 more
wiley   +1 more source

Nerve block techniques utilized in post-bariatric surgery: a narrative review. [PDF]

BMC Surg
Xiao H, Du Y, Li G, Deng Y, Ren Y.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Combined medetomidine, midazolam, and butorphanol anesthesia in mice has a central stress-relieving effect similar to that of isoflurane anesthesia. [PDF]

J Vet Med Sci
Yokosuka M, Osaka M, Tohei A.
europepmc   +1 more source

Myocardial Infarction and Subdural Hematoma Presenting a Neurosurgical Anesthetic Challenge: Successful Management With Scalp Block and Dexmedetomidine Infusion. [PDF]

Cureus
Postiga A, Coutinho ML, Portela E Silva R, Almeida C, Matias F.   +4 more
europepmc   +1 more source

Ultrasound image-based paravertebral nerve block combined with general anesthesia in laparoscopic radical resection of esophageal cancer : Paravertebral nerve block versus general anesthesia in the treatment of esophageal cancer: a randomized controlled trial. [PDF]

World J Surg Oncol
Yang T, He Y.
europepmc   +1 more source