Results 71 to 80 of about 163,705 (301)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Single injection thoracic paravertebral block (TPVB) for breast surgery in morbidly obese patient

Asian Journal of Oncology, 2017
Morbidly obese (MO) patients with associated restrictive airway disease, obstructive sleep apnea, and coronary artery disease pose challenge to an anesthesiologist.
Anita Kulkarni, Vedapadmapriya Selvakumar, Namrata Gupta   +2 more
doaj   +1 more source

Intravenous Regional Anesthesia Using a Forearm Tourniquet: A Safe and Effective Technique for Outpatient Hand Procedures

HAND, 2018
Background: Bier block provides anesthesia of an entire extremity distal to the tourniquet without necessitating direct injection at the surgical site.
Natalie H. Vaughn, Niraja Rajan, M. Darowish   +2 more
semanticscholar   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

A Single‐Component Adhesive Sponge Based on Blood‐Triggered and Autopenetrative Adhesion for Robust Vascular Closure

Advanced Science, EarlyView.
This study presents MonoSeal, a single‐component adhesive sponge powered by the novel Autopenetrative Adhesion (APA) mechanism. Unlike traditional adhesives, which require external stimuli, APA enables strong tissue adhesion under dynamic, high‐pressure bleeding conditions. MonoSeal's ability to autonomously seal large‐size arterial defects underscores
Rong Wang, Weishi Zheng, Yuxuan Huang, Rui Zhang, Yi Zhang, Jingying Yan, Yuqing Gu, Jingyun Xi, Tun Yuan, Hua Su, Xianzhu Zhang, Xiaozhao Wang, Shaohui Xiong, Zhenfeng Cheng, Hongwei Ouyang, Yi Hong   +15 more
wiley   +1 more source

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

Quadratus lumborum block as a component of analgesia in laparoscopic cholecystectomy

Медицина неотложных состояний
Laparoscopic cholecystectomy is a minimally invasive procedure. However, it can cause severe postoperative pain, and sometimes chronic pain. This pain results from several causes: trocar insertion, wound healing, surgical manipulation with the ...
S.M. Chooklin, S.S. Chuklin
doaj   +1 more source

Bupivacaína 0,15% hipobárica versus lidocaína 0,6% hipobárica para raquianestesia posterior em cirurgia anorretal ambulatorial Bupivacaína 0,15% hipobárica versus lidocaína 0,6% hipobárica para raquianestesia posterior en cirugía anorrectal ambulatorial Hypobaric 0.15% bupivacaine versus hypobaric 0.6% lidocaine for posterior spinal anesthesia in outpatient anorectal surgery

Revista Brasileira de Anestesiologia, 2010
JUSTIFICATIVA E OBJETIVOS: Baixas doses de bupivacaína e lidocaína têm sido usadas para raquianestesia em cirurgia ambulatorial. O objetivo deste estudo foi comparar a bupivacaína com a lidocaína ambas em solução hipobárica em pacientes ambulatoriais de ...
Luiz Eduardo Imbelloni, Marildo A Gouveia, José Antonio Cordeiro   +2 more
doaj   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source