Results 1 to 10 of about 95,844 (228)
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
arxiv +4 more sources
THE ADMINISTRATION OF ANESTHETICS. [PDF]
JAMA: The Journal of the American Medical Association, 1898 A man who desires to study medicine can find many places in Chicago where they will undertake to teach him, but I do not know of any place where they will teach him to administer anesthetics. There are many places where he may learn but no place where any provision is made for properly teaching the subject. The student is not left to his own resources
D. H. GALLOWAY
openalex +4 more sources
On the action potential as a propagating density pulse and the role of anesthetics [PDF]
Biophys. Rev. Letters 2 (2007) 57-78, 2006 The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory. Particularly striking is the finding of reversible heat changes, thickness and phase changes of the membrane during ...
ANDREW D. JACKSON +13 more
arxiv +4 more sources
The free energy of biomembrane and nerve excitation and the role of anesthetics [PDF]
BBA - Biomembranes 1860 (2018) 2145-2153, 2018 In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane.
Heimburg, Thomas +3 more
arxiv +3 more sources
Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]
Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages
537-545, 2016 Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
Brooks, NJ +7 more
arxiv +5 more sources
Characterization of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]
arXiv, 2016 Several experiments provide evidence that specialized brain regions functionally interact and reveal that the brain processes and integrates information in a specific and structured manner. Networks can be applied to model brain functional activities, providing means to characterize and quantify this structured form of organization.
Padovani, Eduardo C.
arxiv +2 more sources
Characterization of the Community Structure of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]
arXiv, 2016 One of the main goals of neuroscience is to understand how an organism's cognitive capacities or physiological states are potentially related to brain activities that involve the interaction of multiple brain structures and cortical areas. A key feature of functional brain networks is that they are modularly structured, and this modular architecture is
Padovani, Eduardo C.
arxiv +2 more sources
Structure and Dynamics of Brain Lobe's Functional Networks at the Onset of Anesthesia-Induced Loss of Consciousness [PDF]
arXiv, 2016 Anesthetic agents are neurotropic drugs capable of inducing significant alterations in the thalamocortical system, promoting a profound decrease in awareness and level of consciousness. There is experimental evidence that general anesthesia affects large-scale functional networks, leading to alterations in the brain's state.
Padovani, Eduardo C.
arxiv +2 more sources
Anesthetics or anesthetic techniques and cancer surgical outcomes: a possible link [PDF]
Korean Journal of Anesthesiology, 2021 As of 2018 cancer is responsible for almost 9.6 million deaths annually and, with an aging population, the incidence of cancer is expected to continue to rise. Surgery is an important treatment modality for patients with solid organ cancers.
Azeem Alam +4 more
doaj +1 more source