Results 31 to 40 of about 89,380 (260)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Performance of Local Anesthesia with Lidocaine among Opium Addicts and Non-Addicts; a Case Control Study

Archives of Academic Emergency Medicine, 2018
Introduction: Compared to ordinary people, addicts usually have a lower pain threshold. The current work attempts to compare the performance of local analgesia with lidocaine among opium addicts and non-addicts.
Alireza Majidi, Tala Shahhosseini, Sadrolla Mahmoudi   +2 more
doaj   +1 more source

Determination of Optimal Doses and Minimum Effective Concentrations of Tricaine Methanesulfonate, 2-Phenoxyethanol and Eugenol for Laboratory Managements in Nile Tilapia (Oreochromis niloticus)

Animals, 2021
Anesthetic agents are often used in fish experiments to reduce the stress and struggle and to improve animal welfare. The present study aimed to determine the optimal doses and serum minimum effective concentration (MEC) of tricaine methanesulfonate (MS ...
Tirawat Rairat, Yu Chi, Chia-Yu Hsieh, Yi-Kai Liu, Niti Chuchird, Chi-Chung Chou   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Extracorporeal cardiopulmonary resuscitation in a large tertiary center in the Czech Republic: three years’ experience and future directions

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Extracorporeal resuscitation (ECPR) has been shown to improve outcomes in out-of-hospital cardiac arrest (OHCA). It is, however, not the standard of care.
Filip Burša, Michal Frelich, Peter Sklienka, Marek Bebej, Juraj Rodina, Nela Walachová, Jan Varady, Jan Neiser, Radan Swaczyna, Zuzana Kučerová, Marcela Káňová, David Holeš, Michaela Lišková, Michal Burda, Martin Porzer, Jan Máca   +15 more
doaj   +1 more source

Remifentanil-based propofol-supplemented vs. balanced sevoflurane-sufentanil anesthesia regimens on bispectral index recovery after cardiac surgery: a randomized controlled study [PDF]

Anesthesia and Pain Medicine, 2020
Background The present study was to compare the potential impact of remifentanil-based propofol-supplemented anesthesia regimen vs. conventional sevoflurane-sufentanil balanced anesthesia on postoperative recovery of consciousness indicated by bispectral
Tae-Yun Sung, Dong-Kyu Lee, Jiyon Bang, Jimin Choi, Saemi Shin, Tae-Yop Kim   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

All local anesthetics bind to the biomembrane by its nitrogen atom in the molecule [PDF]

, 2004
P(論文)The interaction between various local anesthetics and the phospholipid membrane was examined by ^1HNMR (Nuclear Magnetic Resonance) spectroscopy. In order to measure the extent of proximity of various local anesthetics to the membrane, We examinined
26618, 26617, Masahiro, KOKUBU, 26619, Kazuaki, ODA, KUDO, Masaru, KOKUBU, Masahiro, SHINYA, Noboru, 26621, ODA, Kazuaki, 26620, OHKE, Hanako, 26616, KAWAI, Takurou, Masaru, KUDO, Noboru, SHINYA, Takurou, KAWAI, Hanako, OHKE   +17 more
core  

Quantifying heterogeneity in an animal model of acute respiratory distress syndrome, a comparison of inspired sinewave technique to computed tomography

Scientific Reports
The inspired sinewave technique (IST) is a non-invasive method to measure lung heterogeneity indices (including both uneven ventilation and perfusion or heterogeneity), which reveal multiple conditions of the lung and lung injury.
Minh C. Tran, Douglas C. Crockett, Tu K. Tran, Phi A. Phan, Formenti Federico, Richard Bruce, Gaetano Perchiazzi, Stephen J. Payne, Andrew D. Farmery   +8 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source