Results 51 to 60 of about 89,380 (260)

Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes [PDF]

, 2002
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process
Blanton, Michael P., Arias, Hugo Rubén
core   +1 more source

A Systematic Review of Perioperative Nerve Blocks for Cleft Lip and Palate Surgeries

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Establishing a successful perioperative technique for better outcomes remains a priority in cleft surgery. In the present review, the safety and efficacy of nerve blocks for cleft lip and cleft palate are evaluated.
Ravi Kerur, Binita Mallapur, Purvashree Deshmukh, Rajesh Powar   +3 more
doaj   +1 more source

Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats

Molecules, 2020
Anesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery.
Chih-Cheng Wu, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Ching-Ping Yang, Chun-Jung Chen   +8 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Intraoperative anesthetics administered by group.

, 2022
Intraoperative anesthetics administered by group.
Valerie Banner-Goodspeed (4692904), Thy B. Nguyen (12530535), Nadav Levy (8196867), Ariel L. Mueller (10501025), Jessica Yu (4413442), Victor Novack (11880), Marie McGourty (13839697), Tamara D. Rozental (13839703), Galina Korsunsky (13839700), Adeel A. Faruki (13839691), Sam Proeschel (13839694), Doris-Vanessa Gasangwa (6201419), Brian P. O’Gara (13839706), Victoria Ip (3339306)   +13 more
core   +1 more source

The potential anti-tumor effect of anesthetics on cancer by regulating autophagy

Frontiers in Pharmacology
Autophagy is a conserved, cellular self-degradation system that is essential for maintaining intracellular homeostasis. Increasing evidence suggests that autophagy plays an important dual regulatory role in the development of many human diseases, such as
Tiantian Wang, Tiantian Wang, Tiantian Wang, Zhixia Zhou, Kai Jiang, Yin Wang, Peifeng Li, Shoushi Wang   +7 more
doaj   +1 more source

Anesthetic neurotoxicity in the developing brain: an update on the insights and implications for fetal surgery [PDF]

Anesthesia and Pain Medicine
This review describes an in-depth analysis of the neurotoxicity associated with the anesthetic agents used during fetal surgery, intending to highlight the importance of understanding the effects of general anesthetics on the developing brain ...
Denise Cinquegrana, Sri Harsha Boppana, David Berman, Truc-Anh T. Nguyen, Ahmet A. Baschat, Jamie Murphy, C. David Mintz   +6 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Update on local anesthetics

, 2010
PURPOSE OF REVIEW: Local anesthetics are not only used as drugs to block the sodium channel to provide analgesia and antiarrhythmic action. The purpose of this review is to highlight the new indications and limitations of this class of drugs.
Alain Borgeat, Aguirre, J, José Aguirre, Borgeat, A   +3 more
core   +1 more source

Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Frontiers in Pharmacology
Cervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the
Linyan Deng, Linyan Deng, Linyan Deng, Tingting Wang, Tingting Wang, Tingting Wang, Qiaofeng Zhang, Qiaofeng Zhang, Qiaofeng Zhang, Shaofang Shu, Shaofang Shu, Shaofang Shu, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +14 more
doaj   +1 more source