Results 71 to 80 of about 82,172 (314)

Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats

Molecules, 2020
Anesthetics, particularly volatile anesthetics, have been shown to impair glucose metabolism and cause hyperglycemia, closely linking them with mortality and morbidity as related to surgery.
Chih-Cheng Wu, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Ching-Ping Yang, Chun-Jung Chen   +8 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The potential anti-tumor effect of anesthetics on cancer by regulating autophagy

Frontiers in Pharmacology
Autophagy is a conserved, cellular self-degradation system that is essential for maintaining intracellular homeostasis. Increasing evidence suggests that autophagy plays an important dual regulatory role in the development of many human diseases, such as
Tiantian Wang, Tiantian Wang, Tiantian Wang, Zhixia Zhou, Kai Jiang, Yin Wang, Peifeng Li, Shoushi Wang   +7 more
doaj   +1 more source

Anesthetic neurotoxicity in the developing brain: an update on the insights and implications for fetal surgery [PDF]

Anesthesia and Pain Medicine
This review describes an in-depth analysis of the neurotoxicity associated with the anesthetic agents used during fetal surgery, intending to highlight the importance of understanding the effects of general anesthetics on the developing brain ...
Denise Cinquegrana, Sri Harsha Boppana, David Berman, Truc-Anh T. Nguyen, Ahmet A. Baschat, Jamie Murphy, C. David Mintz   +6 more
doaj   +1 more source

Preventive but Not Therapeutic Topical Application of Local Anesthetics Can Inhibit Experimental Epidermolysis Bullosa Acquisita in Mice

Frontiers in Immunology, 2021
Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disorder characterized and caused by autoantibodies against type VII collagen (COL7).
Lifang Wen, Lifang Wen, Xiaoru Dong, Xiaoru Dong, Qing Li, Gabriele Schramm, Bing Zhang, Detlef Zillikens, Ralf J. Ludwig, Frank Petersen, Xinhua Yu   +10 more
doaj   +1 more source

Update on local anesthetics

, 2010
PURPOSE OF REVIEW: Local anesthetics are not only used as drugs to block the sodium channel to provide analgesia and antiarrhythmic action. The purpose of this review is to highlight the new indications and limitations of this class of drugs.
Alain Borgeat, Aguirre, J, José Aguirre, Borgeat, A   +3 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Frontiers in Pharmacology
Cervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the
Linyan Deng, Linyan Deng, Linyan Deng, Tingting Wang, Tingting Wang, Tingting Wang, Qiaofeng Zhang, Qiaofeng Zhang, Qiaofeng Zhang, Shaofang Shu, Shaofang Shu, Shaofang Shu, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +14 more
doaj   +1 more source

Effects of Anesthetics on Barrier Tissue Function

, 2019
Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are ...
Haichun Ma, Yanhui Li, Zhaoping Xue, Fujing Wang, Changlei Cui   +4 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source