Results 181 to 190 of about 1,731 (219)

Liberal use of ketamine is on the rise! A critical warning!! [PDF]

Surg Neurol Int
Ghaly RF.
europepmc   +1 more source

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Ketamine a dissociative anesthetic: Neurobiology and biomolecular exploration in depression

Chemico-Biological Interactions, 2020
Ketamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs that influence monoamine neurotransmitters including noradrenaline, dopamine, or serotonin. Ketamine is thought to act by blocking N-methyl-d-aspartate (NMDA) receptors in the brain, which interact with the amino acid ...
Guo-Liang, Liu, Yun-Feng, Cui, Chang, Lu, Peng, Zhao   +3 more
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Patinet Acceptance of Dissociative Anesthetics

Plastic and Reconstructive Surgery, 1983
A prospective study was undertaken to evaluate the efficacy, safety, and patient acceptance of low-dose ketamine when used to diminish the pain of local anesthetic injections. The role of diazepam in preventing the untoward psychological effects of ketamine was also investigated.
B L, Cunningham, P, McKinney
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Dissociative Anesthetics in the Cat and Dog

Journal of the American Veterinary Medical Association, 1972
SUMMARY Dissociative anesthetic agents have the potential to revolutionize the anesthetic management of the dog and cat. They may become an integral part of a regimen of “balanced anesthesia” in veterinary medicine. The dissociative state produced by these agents is characterized by muscle rigidity and the presence of many reflexes (e.g., swallowing ...
D W, DeYoung, R R, Paddleford, C E, Short   +2 more
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Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring

Clinical Neurophysiology, 2021
Ketamine is an anesthetic drug associated with dissociation. Decreased electroencephalogram alpha (8-13 Hz) and low-beta (13-20 Hz) oscillation power have been associated with ketamine-induced dissociation. We aimed to characterize surface electroencephalogram signatures that may serve as biomarkers for dissociation.We analyzed data from a single-site,
Shubham Chamadia, Jacob Gitlin, Jennifer Mekonnen, Breanna R. Ethridge, Reine Ibala, Katia M. Colon, Jason Qu, Oluwaseun Akeju   +7 more
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A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions

Journal of Affective Disorders, 2021
Dissociation is a treatment-emergent adverse event commonly associated with IV ketamine, often measured using the 23-item Clinician-Administered Dissociative States Scale (CADSS). The objective of this study was to develop a short form version of the CADSS for easier clinical use.Retrospective data of 260 patients with treatment-resistant depression ...
Nelson B. Rodrigues, Roger S. McIntyre, Orly Lipsitz, Yena Lee, Danielle S. Cha, Margarita Shekotikhina, Maj Vinberg, Hartej Gill, Mehala Subramaniapillai, Kevin Kratiuk, Kangguang Lin, Roger Ho, Rodrigo B. Mansur, Joshua D. Rosenblat   +13 more
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Ketamine’s dose related multiple mechanisms of actions: Dissociative anesthetic to rapid antidepressant

Behavioural Brain Research, 2020
Ketamine induces safe and effective anesthesia and displays unusual cataleptic properties that gave rise to the term dissociative anesthesia. Since 1970, clinicians only utilized the drug as an anesthetic or analgesic for decades, but ketamine was found to have rapid acting antidepressant effects in 1990s. Accumulated evidence exhibits NMDAR antagonism
Eli, Lavender, Mika, Hirasawa-Fujita, Edward F, Domino   +2 more
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Local anesthetics reduce the inhibitory neurotransmitter-induced current in dissociated hippocampal neurons of the rat

European Journal of Pharmacology, 1995
The effects of local anesthetics on amino acid-induced currents were examined using the whole-cell configuration of the patch clamp technique in dissociated hippocampal pyramidal neurons of the rat. Lidocaine (3 mM) decreased the glycine-induced Cl- current (Gly-ICl) more potently (to 46% of the control value) than the gamma-aminobutyric acid-induced ...
M, Hara, Y, Kai, Y, Ikemoto
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