Results 91 to 100 of about 6,244,144 (279)
A high-throughput approach for identification of novel general anesthetics. [PDF]
PLoS ONE, 2009 Anesthetic development has been a largely empirical process. Recently, we described a GABAergic mimetic model system for anesthetic binding, based on apoferritin and an environment-sensitive fluorescent probe.
Wendy A Lea +6 more
doaj +1 more source
General Anesthetics and The Developing Brain [PDF]
, 2011 Millions of children undergo seemingly safe general anesthesia and sedation to facilitate procedures located in surgery, imaging suites, radiology suites, emergency departments, and intensive care units.
Stanz, Tracy A
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher +5 more
wiley +1 more source
The free energy of biomembrane and nerve excitation and the role of anesthetics
, 2018 In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference ...
Heimburg, Thomas +3 more
core +1 more source
Journal of Neuroscience, 2013 The molecular targets and neural circuits that underlie general anesthesia are not fully elucidated. Here, we directly demonstrate that Kv1-family (Shaker-related) delayed rectifier K+ channels in the central medial thalamic nucleus (CMT) are important ...
M. Lioudyno +7 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective The National Institute of Health and Care Excellence (NICE) criteria for osteoarthritis (OA) obviate the need for physical examination or imaging, and their use may improve timely diagnosis of OA. However, they have not been validated. Methods Within a larger study of individuals with type 2 diabetes, participants with and without self ...
Lauren K. King +6 more
wiley +1 more source
Intravenous anesthetics have differential effects on human potassium channels
Acta Biochimica et Biophysica SinicaGeneral anesthetics are widely used in the clinic and greatly promote the development of surgery. However, the incidence of cardiovascular and respiratory complications caused by general anesthetics is still high, and the underlying mechanisms remain ...
Tao Ying +9 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner +12 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones +5 more
wiley +1 more source
Research progress on mitochondrial mechanisms of sensitivity to inhalational anesthetics
Zhongguo linchuang yanjiuExperimental animals and people have different sensitivity to inhalational anesthetics, which is related to the depth of anesthesia during general anesthesia and the perioperative safety of patients.
CHENG Sijing*, WEI Yiyong, WANG Haiying
doaj +1 more source