Results 11 to 20 of about 6,244,144 (279)
General anesthetics inhibit LPS-induced IL-1β expression in glial cells. [PDF]
PLoS ONE, 2013 BACKGROUND: Glial cells, including microglia and astrocytes, are considered the primary source of proinflammatory cytokines in the brain. Immune insults stimulate glial cells to secrete proinflammatory cytokines that modulate the acute systemic response,
Tomoharu Tanaka +5 more
doaj +2 more sources
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
Biophysical Journal, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated
Gray, Ellyn +3 more
core +2 more sources
Burst Suppression: A Review and New Insights [PDF]
Frontiers in Systems Neuroscience, 2014 Burst suppression is a pattern of brain electrical activity characterized by alternating periods of high-amplitude bursts and electrical silence.
Jonathan Dillon Kenny +9 more
doaj +6 more sources
How general anesthetics work: from the perspective of reorganized connections within the brain [PDF]
Korean Journal of Anesthesiology, 2022 General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood.
Teo Jeon Shin +2 more
doaj +1 more source
The impact of preoperative glycated hemoglobin (HbA1c) on postoperative complications after elective major abdominal surgery: a meta-analysis [PDF]
Korean Journal of Anesthesiology, 2022 Background Diabetes is a risk factor for postoperative complications. Previous meta-analyses have shown that elevated glycated hemoglobin (HbA1c) levels are associated with postoperative complications in various surgical populations. However, this is the
Joanna K. L. Wong +5 more
doaj +1 more source
Effects of General Anesthetics on Synaptic Transmission and Plasticity
Current Neuropharmacology, 2021 General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission principally by modulating the function of glutamatergic or GABAergic synapses, respectively, with relative anesthetic agent-specific mechanisms.
J. Platholi, H. Hemmings
semanticscholar +1 more source
Cardiac output and the pharmacology of general anesthetics: a narrative review
Colombian Journal of Anesthesiology, 2023 The relationship between cardiac output and anesthetic drugs is important to anesthesiologists, since cardiac output determines the speed with which a drug infused into the bloodstream reaches its target and the intensity of the drug’s effect.
Elena Simón-Polo +3 more
doaj +1 more source
Medicina, 2022 Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread.
John Michael Bonvini
doaj +1 more source
Molecular mechanisms of general anesthesia [PDF]
Korean Journal of Anesthesiology, 2010 General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission.
Yong Son
doaj +1 more source
Are Local Anesthetics and General Anesthetics Different? [PDF]
Biophysical Journal, 2014 It is widely believed that general and local anesthetics act by different mechanisms. While there is general agreement that the mode of action of general anesthetics is poorly understood, local anesthetics are believed to block voltage-gated sodium channels and thereby affect action potentials in nerves.
Sasse-Middelhoff, Henrike +2 more
openaire +2 more sources