Results 11 to 20 of about 78,145 (311)

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Frontiers in Oncology, 2021
Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Jiaqiang Wang, Chien-shan Cheng, Chien-shan Cheng, Yan Lu, Shen Sun, Shaoqiang Huang   +5 more
doaj   +1 more source

Effect of Local and General Anesthetics on Interfacial Water. [PDF]

PLoS ONE, 2016
Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina, Minghui Shi, Gerald H Pollack   +2 more
doaj   +1 more source

New patents on topical anesthetics. [PDF]

, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano, CANTISANI, CARMEN, D'ANDREA, Vito, Frascani, F, MACALUSO, LAURA, paolino, giovanni, RICHETTA, Antonio Giovanni   +6 more
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Electroencephalogram of Healthy Horses During Inhaled Anesthesia. [PDF]

, 2015
BackgroundPrevious study of the diagnostic validity of electroencephalography (EEG) to detect abnormalities in equine cerebral cortical function relied on the administration of various drugs for sedation, induction, and maintenance of general anesthesia ...
Aleman, MR, Brosnan, RJ, Fletcher, DJ, Holliday, TA, Kass, PH, LeCouteur, RA, Steffey, EP, Tharp, B, Williams, DC   +8 more
core   +1 more source

Anesthetic management of a 9-year-old girl with Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay syndrome: airway difficulties and postoperative apnea during tendon surgery [PDF]

Anesthesia and Pain Medicine
Background This case report described the anesthetic management and postoperative challenges of a patient diagnosed with Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay (CLIFAHDD) syndrome who underwent tenomyotomy of ...
Jessica G. Santos, Alexandre C. Buffon
doaj   +1 more source

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Frontiers in Synaptic Neuroscience, 2022
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel, Hugh C. Hemmings Jr., Hugh C. Hemmings Jr.   +2 more
doaj   +1 more source

Transient neurologic symptoms following spinal anesthesia with isobaric mepivacaine: A decade of experience at Toronto Western Hospital [PDF]

, 2018
Background: Transient neurologic symptoms (TNSs) can be distressing for patients and providers following uneventful spinal anesthesia. Spinal mepivacaine may be less commonly associated with TNS than lidocaine; however, reported rates of TNS with ...
Abdallah, Faraj W., Behboudi, Minou, Brull, Richard, MacFarlane, Alan, Sankar, Ashwin   +4 more
core   +2 more sources

Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain

Frontiers in Neurology, 2022
General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community.
Jiaojiao Wang, Jiaojiao Wang, Zhihui Liu
doaj   +1 more source

Desflurane Selectively Suppresses Long-latency Cortical Neuronal Response to Flash in the Rat [PDF]

, 2009
Background—The effect of inhalational anesthetics on sensory-evoked unit activity in the cerebral cortex has been controversial. Desflurane has desirable properties for in vivo neurophysiologic studies but its effect on cortical neuronal activity and ...
Hudetz, Anthony G., Imas, Olga A., Vizuete, Jeannette A.   +2 more
core   +2 more sources

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Cell Reports, 2018
Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentameric
Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue   +7 more
doaj   +1 more source