Results 11 to 20 of about 45,734 (242)

Structural interplay of anesthetics and paralytics on muscle nicotinic receptors

Nature Communications, 2023
General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by potentiating inhibitory ion channels and inhibiting excitatory ion channels, with the net effect of ...
Umang Goswami, Md Mahfuzur Rahman, Jinfeng Teng, Ryan E. Hibbs   +3 more
doaj   +1 more source

The effect of lidocaine on apoptotic neurodegeneration in the developing mouse brain [PDF]

Korean Journal of Anesthesiology, 2014
BackgroundGeneral anesthetics induce neuronal apoptosis in the immature brain. Regional anesthesia using local anesthetics can be an alternative to general anesthesia.
Ji-Hyun Lee, Yong-Hee Park, Hyun-Gul Song, Hee-Pyoung Park, Hee-Soo Kim, Chong-Sung Kim, Jin-Tae Kim   +6 more
doaj   +1 more source

Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration

BMC Anesthesiology, 2021
Background Although general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function remains unclear. We aimed to investigate the effects of general anesthetics on spontaneous respiration in non-
Xuechao Hao, Mengchan Ou, Yu Li, Cheng Zhou   +3 more
doaj   +1 more source

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Frontiers in Oncology, 2021
Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Jiaqiang Wang, Chien-shan Cheng, Chien-shan Cheng, Yan Lu, Shen Sun, Shaoqiang Huang   +5 more
doaj   +1 more source

Effect of Local and General Anesthetics on Interfacial Water. [PDF]

PLoS ONE, 2016
Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina, Minghui Shi, Gerald H Pollack   +2 more
doaj   +1 more source

Anesthetic management of a 9-year-old girl with Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay syndrome: airway difficulties and postoperative apnea during tendon surgery [PDF]

Anesthesia and Pain Medicine
Background This case report described the anesthetic management and postoperative challenges of a patient diagnosed with Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay (CLIFAHDD) syndrome who underwent tenomyotomy of ...
Jessica G. Santos, Alexandre C. Buffon
doaj   +1 more source

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Frontiers in Synaptic Neuroscience, 2022
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel, Hugh C. Hemmings Jr., Hugh C. Hemmings Jr.   +2 more
doaj   +1 more source

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Cell Reports, 2018
Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentameric
Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue   +7 more
doaj   +1 more source

Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain

Frontiers in Neurology, 2022
General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community.
Jiaojiao Wang, Jiaojiao Wang, Zhihui Liu
doaj   +1 more source

A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

Brain Sciences, 2014
The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain ...
Sunny Chiao, Zhiyi Zuo
doaj   +1 more source