Results 191 to 200 of about 952,770 (304)

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel, Henning De May, Lauren Anderson, Lorél Y. Medina, Ellie Kennedy, Erica Flores, John O'Rourke, Marian Olewine, Irina Lagutina, Lillian Fitzpatrick, Fred Shultz, Donna F. Kusewitt, Eric Bartee, Sarah Adams, Achraf Noureddine, Rita E. Serda   +15 more
wiley   +1 more source

Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review. [PDF]

Life (Basel)
Cahill T, Matveychuk N, Hardiman E, Rosner H, Farrell D, Hardiman G.   +5 more
europepmc   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

A computational approach to evaluate how molecular mechanisms impact large-scale brain activity. [PDF]

Nat Comput Sci
Sacha M, Tesler F, Cofre R, Destexhe A.
europepmc   +1 more source

Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui, Jordan Beurton, Claire Medemblik, Ludivine Hugoni, Igor Clarot, Ariane Boudier, Youri Arntz, Marcella De Giorgi, Jérôme Combet, Guillaume Fleith, Eric Mathieu, Naji Kharouf, Leyla Kocgozlu, Benoît Heinrich, Damien Favier, Michael Brender, Fouzia Boulmedais, Pierre Schaaf, Benoît Frisch, Philippe Lavalle   +19 more
wiley   +1 more source

Rapid Health Evaluation of Analgesia with Long-Acting Local Anesthesia After Hip and Knee Arthroplasty. [PDF]

Integr Pharm Res Pract
Zhang X, Li M, Lei L.
europepmc   +1 more source

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G. Moreels, Joris Messens, Ana Beloqui   +9 more
wiley   +1 more source

Microtubule-modulating drugs alter sensitivity to isoflurane in mice. [PDF]

BMC Anesthesiol
Li N, You Z, Ren Y, Kim HH, Yang J, Li G, Doheny JT, Ding W, Xia S, Wang S, Zhou X, Wu X, Shen S, Dong Y, Xie Z, Chen L, Mao J, Martyn JAJ.   +17 more
europepmc   +1 more source

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management. [PDF]

Curr Issues Mol Biol
DiMaria S, Mangano N, Bruzzese A, Bartula B, Parikh S, Costa A.   +5 more
europepmc   +1 more source