Results 231 to 240 of about 6,404,771 (353)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Pain Control Paradigms: A Comparative Review of Anesthesia Techniques in Trigeminal Neuralgia Therapy. [PDF]

Pain Ther
Lai L, Xie K.
europepmc   +1 more source

General anesthetics in pediatric anesthesia: influences on the developing brain.

Current Drug Targets, 2012
M. McCann, S. Soriano
semanticscholar   +1 more source

Enzyme‐Regulated Extended Swelling of Hydrogels for Dehiscence‐Less Tissue Expansions

Advanced Functional Materials, EarlyView.
An interpenetrating hydrogel network with swelling under regulation by enzymatic degradation (INSURED) is fabricated to avoid dehiscence. INSURED remains structurally intact post‐implantation, while HYAL injection enables control over the onset and rate of swelling.
Byung Ik Park, Dong‐yup Lee, Sungsoo Lim, JangHyuk Kim, Min‐Gyu Lee, Chang Seo Park, Hyeonuk Na, Yong Eun Cho, Yun Hyeok Lee, Junsang Doh, Jeong‐Yun Sun   +10 more
wiley   +1 more source

From neurotoxicity to neuroprotection: Rethinking GABA_AR-targeting anesthetics. [PDF]

Cell Biol Toxicol
Li Y, Yang H, Liu L, Jiang L, Xie P, Wang X, Cong X, Zhu R, Lu Z, Sun M, Zhang J.   +10 more
europepmc   +1 more source

Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood.

Journal of the American Medical Association (JAMA), 2016
Lena S. Sun, Guohua Li, Tonya L. K. Miller, C. Salorio, M. Byrne, D. Bellinger, C. Ing, R. Park, J. Radcliffe, S. Hays, C. DiMaggio, Timothy Cooper, V. Rauh, L. Maxwell, Ahrim Youn, F. McGowan   +15 more
semanticscholar   +1 more source

Buckling‐Resistant and Trace‐Stacked (BRATS) Design Enables Aid‐Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response

Advanced Functional Materials, EarlyView.
Buckling‐resistant and trace‐stacked (BRATS) intracortical microelectrode arrays (MEAs) eliminate the need for insertion aid and complex surgical setup, resulting in minimal inflammatory tissue response, compared to conventional flexible MEAs inserted with aid. Trace stacking effectively doubled the channel count without increasing the MEA shank width,
May Yoon Pwint, Delin Shi, X. Tracy Cui
wiley   +1 more source

Platelet Rich Plasma for the Therapy of the Lumbar Facet Joint Syndrome: A Prospective Study About CT-Guided Facet Joint Injections With PRP Compared to Local Anesthetics. [PDF]

Orthop Rev (Pavia)
Baltzer AW, Enneper J, Baltzer LM, Godde G.   +3 more
europepmc   +1 more source

Inhibition of learning and memory by general anesthetics

Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 2011
Dian-shi Wang, B. Orser
semanticscholar   +1 more source

Towards High‐Acuity Vision Restoration: Hybrid Retinal Prosthesis Composed of a High‐Density Multielectrode Array Integrated With Glutamatergic Cells

Advanced Functional Materials, EarlyView.
This work introduces a novel Hybrid Retinal Implant (HRI), composed of a high‐density electrode array integrated with glutamatergic neurons to overcome key limitations of current retinal prostheses. The significant reduction of activation threshold and of electrode cross‐talk yields in an improved spatial resolution.
Nairouz Farah, Amos Markus, Gal Shpun, Yoav Chemla, Erel Lasnoy, Tamar Azrad‐Leibovitch, Fikre Fentahon, Zeev Zalvesky, Yossi Mandel   +8 more
wiley   +1 more source