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Neurotoxicity of General Anesthetics: An Update
Current Pharmaceutical Design, 2012Though general anesthetics have now been used clinically for well over a century, both their mechanisms of action as well as the nature of any potentially neurotoxic side effects remain elusive. With roughly 234 million people undergoing surgery each year worldwide, it remains imperative that any potentially deleterious effects of anesthetics be ...
Zhongcong Xie, Phillip E. Vlisides
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International Anesthesiology Clinics, 1994
General anesthesia is the most common form of anesthetic management for ambulatory surgery. Patients, in general, prefer general anesthesia because it is less anxiety provoking. During the last decade, the availability of several short-acting agents with high clearance has made general anesthetic techniques much safer and more predictable for ...
Carmen R. Green, Sujit K. Pandit
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General anesthesia is the most common form of anesthetic management for ambulatory surgery. Patients, in general, prefer general anesthesia because it is less anxiety provoking. During the last decade, the availability of several short-acting agents with high clearance has made general anesthetic techniques much safer and more predictable for ...
Carmen R. Green, Sujit K. Pandit
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Neurotoxicity of general anesthetics in children: evidence and uncertainties
Current opinion in pediatrics, 2019Purpose of review Compelling evidence in animal models that, under some conditions, general anesthetics and sedatives produce changes in the brain and persistent impairments in learning, memory, and behavior. The present review summarizes recent clinical
D. Bellinger, J. Calderon
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Evaluation of a General Anesthetic
JAMA, 1981Isoflurane is a nonflammable halogenated ether used as an inhalational anesthetic. It has physical, pharmacologic, and clinical properties similar to those of halothane and enflurane; however, it differs in important respects from both. It is a more potent muscle relaxant than halothane and does not have the CNS irritant properties of enflurane.
Michael H. M. Dykes, Harry W. Linde
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Journal of Medicinal Chemistry, 2017
A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized.
Linlin Qin +9 more
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A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized.
Linlin Qin +9 more
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2006
Publisher Summary In surgical practice, the term general anesthesia (narcosis) presently refers to the condition of an organism with a reversible loss of consciousness at a controlled level of nervous system suppression. It includes components such as analgesia (absence of pain), amnesia (absence of memory), and suppression of reflexes such as ...
Victor J. Hruby, Ruben Vardanyan
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Publisher Summary In surgical practice, the term general anesthesia (narcosis) presently refers to the condition of an organism with a reversible loss of consciousness at a controlled level of nervous system suppression. It includes components such as analgesia (absence of pain), amnesia (absence of memory), and suppression of reflexes such as ...
Victor J. Hruby, Ruben Vardanyan
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Anaphylaxis to General Anesthetics
2010The incidence of hypersensitivity reactions to anesthetics is estimated 1 in 13,000 anesthetics up to 1 in 3,180. The rate of mortality ranges between 3 and 9%. 90% of reactions appear at anesthesia induction. Cardiovascular collapse and bronchospasm are more frequent in IgE-dependent reactions.
D. Anne Moneret-Vautrin +1 more
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