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General Anesthetics

2006
Publisher Summary In surgical practice, the term general anesthesia (narcosis) presently refers to the condition of an organism with a reversible loss of consciousness at a controlled level of nervous system suppression. It includes components such as analgesia (absence of pain), amnesia (absence of memory), and suppression of reflexes such as ...
Victor J. Hruby, Ruben Vardanyan
openaire   +3 more sources

Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics.

Journal of Medicinal Chemistry, 2017
A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized.
Linlin Qin   +9 more
semanticscholar   +1 more source

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

Glia, 2016
Astrocytes represent a major non‐neuronal cell population actively involved in brain functions and pathologies. They express a large amount of gap junction proteins that allow communication between adjacent glial cells and the formation of glial networks.
Xinhe Liu   +6 more
semanticscholar   +1 more source

General Anesthetic Techniques in Ruminants

Veterinary Clinics of North America: Food Animal Practice, 1996
Sedation, anesthesia, protection of the airway during general anesthesia, and control of pain in the perioperative period are important considerations in the management of sheep, goats, and cattle. Though ruminants are classically considered farm animals and are often intended for the production of food and fiber, these species are used extensively in ...
Gwendolyn L. Carroll   +1 more
openaire   +3 more sources

General anesthetics and cytotoxicity: possible implications for brain health

Drug and chemical toxicology (New York, N.Y. 1978), 2017
Background: The search for agents that bring about faster induction and quicker recovery in the operating room have yielded numerous anesthetics whose mechanisms of action and potential toxic side effects remain unknown, especially in the young and aging
R. Armstrong   +4 more
semanticscholar   +1 more source

Antagonism of general anesthetics

International Congress Series, 2005
Abstract Despite many research efforts on the mechanisms of anesthesia, there have been no reports on the anesthesia antagonists. It is well recognized that the dose–response curves of anesthetics are extremely steep. Availability of anesthesia antagonists would benefit anesthesia practice at emergency situations when the anesthesia becomes ...
Ikuo Ueda, Tsuneo Tatara, Hiroshi Kamaya
openaire   +2 more sources

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Anesthesiology, 2016
Background:Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood.
S. Avramescu   +8 more
semanticscholar   +1 more source

General anesthetics and the developing brain

Current Opinion in Anaesthesiology, 2009
General anesthetics and sedatives are used in millions of children every year to facilitate surgical procedures, imaging studies, and sedation in operating rooms, radiology suites, emergency departments, and ICUs. Mounting evidence from animal studies suggests that prolonged exposure to these compounds may induce widespread neuronal cell death and ...
Andreas W. Loepke, George K. Istaphanous
openaire   +3 more sources

General anesthetic allergy testing

Current Allergy and Asthma Reports, 2008
Anaphylaxis in the setting of general anesthesia is a rare but potentially lethal event. The investigation of severe reactions is important for confirming the clinical diagnosis and identifying likely causative agents and safe agents that may be used in the future. Many comprehensive reports have described the testing protocol of individual specialized
Garry Donnan, Karl Bleasel, Gary Unglik
openaire   +2 more sources

General and Local Anesthetics

2019
Anesthetising the older surgical patient present its own unique challenges. Heterogeneity is the most consistent feature of this age group and preoperative assessment and optimisation must take into account the varying comorbidities, extent of physiological ageing, frailty and the size of surgery which will determine patient outcome. Breast surgery can
Irwin Foo, Faisal Jafar
openaire   +2 more sources

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