Results 91 to 100 of about 736,541 (316)

Mechanism of Anesthetic Action: Oxygen Pathway Perturbation Hypothesis [PDF]

open access: yesMedical Hypothese (2001) 57(5): 619-627., 2001
Although more than 150 years have past since the discovery of general anesthetics, how they precisely work remains a mystery. We propose a novel unitary mechanism of general anesthesia verifiable by experiments. In the proposed mechanism, general anesthetics perturb oxygen pathways in both membranes and oxygen-utilizing proteins such that the ...
arxiv  

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

open access: yesAdvanced Science, EarlyView.
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu   +14 more
wiley   +1 more source

Intravenous Emulsified Halogenated Anesthetics Produce Acute and Delayed Preconditioning against Myocardial Infarction in Rabbits

open access: yesAnesthesiology, 2004
Background:Preconditioning against myocardial infarction by volatile anesthetics is well known. The authors tested the hypothesis that new emulsified formulations of halogenated anesthetics administered intravenously reduce myocardial infarct size when ...
P. Chiari   +8 more
semanticscholar   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

open access: yesAdvanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu   +12 more
wiley   +1 more source

Intravenous lipid emulsion for treatment of local anesthetic toxicity

open access: yesTherapeutics and Clinical Risk Management, 2010
M Caroline Kosh, April D Miller, Jill E Michels, , Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy, University of South Carolina Campus, Columbia, South Carolina, USADate of Preparation: 14th July 2010 Conflict ...
M Caroline Kosh   +2 more
doaj  

Effects of Intravenous Anesthetics vs Inhaled Anesthetics on Early Postoperative Sleep Quality and Complications of Patients After Laparoscopic Surgery Under General Anesthesia

open access: yesNature and Science of Sleep, 2021
Shiyi Li,1,* Bijia Song,2,* Yang Li,1 Junchao Zhu1 1Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Anesthesiology, Beijing Friendship Hospital of Capital ...
Li S, Song B, Li Y, Zhu J
doaj  

Characterization of the Community Structure of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]

open access: yesarXiv, 2016
One of the main goals of neuroscience is to understand how an organism's cognitive capacities or physiological states are potentially related to brain activities that involve the interaction of multiple brain structures and cortical areas. A key feature of functional brain networks is that they are modularly structured, and this modular architecture is
arxiv  

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu   +13 more
wiley   +1 more source

Methemoglobinemia presenting in a circumcised baby following application of prilocaine: a case report

open access: yesJournal of Medical Case Reports, 2010
Introduction Local anesthesia with prilocaine has become a routine part of ambulatory circumcision procedures. Methemoglobinemia is a rare but potentially lethal complication of local anesthetics.
Ozgun Gulten   +4 more
doaj   +1 more source

Characterization of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]

open access: yesarXiv, 2016
Several experiments provide evidence that specialized brain regions functionally interact and reveal that the brain processes and integrates information in a specific and structured manner. Networks can be applied to model brain functional activities, providing means to characterize and quantify this structured form of organization.
arxiv  

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