Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites. [PDF]
Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic NaV channel NaChBac have demonstrated that propofol promotes channel activation ...
Bondarenko, Vasyl+12 more
core +1 more source
Propofol Induction Reduces the Capacity for Neural Information Integration: Implications for the Mechanism of Consciousness and General Anesthesia [PDF]
The cognitive unbinding paradigm suggests that the synthesis of cognitive information is attenuated by general anesthesia. Here, we investigated the functional organization of brain activities in the conscious and anesthetized states, based on ...
Byung-Moon Choi+4 more
core +2 more sources
Combined use of intravenous anesthetics and hypothermia in treating refractory status epilepticus
The primary choice of treating refractory status epilepticus (RSE) is intravenous anesthetics, but the seizures of some patients can not get a good control. Thus, other therapies must be combined.
Guo-ping REN, Ying-ying SU
doaj
SYSTEMIC TOXICITY REACTIONS DUE TO EPIDURAL CATHETER DISPLACEMENT [PDF]
"nToxic reactions to local anesthetics may occur due to over dose, accidental intravenous injections or rapid systemic uptake of the drugs. But there have been few reports on toxicity due to displacement of epidural catheters after an initial ...
M H Ghafari+3 more
doaj +2 more sources
Ketamine-Medetomidine General Anesthesia Occurs With Alternation of Cortical Electrophysiological Activity Between High and Low Complex States [PDF]
Anesthetic agents are known to induce a range of alterations in cortical electrophysiological activity, such as the rise of signature patterns, changes in statistical properties, and altered dynamic behavior of neural records. Plenty of methods can be used to monitor these changes, among them complexity metrics demonstrated to have the power to ...
arxiv
Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery [PDF]
Background: The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery.
Brevoord, Daniel+9 more
core +15 more sources
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee+12 more
wiley +1 more source
A Cost Analysis of Carpal Tunnel Release Surgery Performed Wide Awake versus under Sedation. [PDF]
BACKGROUND: Hand surgery under local anesthesia only has been used more frequently in recent years. The purpose of this study was to compare perioperative time and cost for carpal tunnel release performed under local anesthesia ( wide-awake local ...
Al Youha+23 more
core +2 more sources
Background A better understanding of the risk factors for postoperative nausea and vomiting (PONV) could improve patient outcomes. This study aimed to analyze the risk factors for PONV and its onset after third molar impaction surgery, and to demonstrate
Hiroaki Hasegawa+4 more
doaj +1 more source
What We Already Know about This Topic Propofol may better preserve host defenses against cancer Whether cancer recurrence is less likely with propofol than volatile anesthesia remains unknown What This Article Tells Us That Is New The authors conducted a
Zhi-Fu Wu+9 more
semanticscholar +1 more source