Results 101 to 110 of about 5,479,760 (341)

Neurotoxicity Questions Regarding Common Peripheral Nerve Block Adjuvants in Combination with Local Anesthetics

Current Opinion in Anaesthesiology, 2015
Purpose of review This review outlines the analgesic role of perineural adjuvants for local anesthetic nerve block injections, and evaluates current knowledge regarding whether adjuvants modulate the neurocytologic properties of local anesthetics. Recent
J. Knight, N. Schott, M. Kentor, B. Williams   +3 more
semanticscholar   +1 more source

Pain and efficacy of local anesthetics for central venous access

, 2008
William C Culp Jr1, Mohammed Yousaf2, Benjamin Lowry1, Timothy C McCowan3, William C Culp21Division of Cardiothoracic Anesthesiology, Scott and White Hospital, The Texas A&M University College of Medicine, Temple, TX, USA; 2Division of ...
William C Culp Jr, Mohammed Yousaf, William C Culp, Timothy C McCowan, Benjamin Lowry   +4 more
core  

Local Anesthetics: Review of Pharmacological Considerations

, 2023
Local anesthetics have an impressive history of efficacy and safety in medical and dental practice. Their use is not so regular, and the negative effects are so low, that providers can overlook a lot of their pharmacotherapeutic principles understandable.
Abdumanobov Mashhurbek Mansur o’g’li
core   +1 more source

Current Concepts of the Mechanism of Action of Local Anesthetics

, 1981
Recent experiments are reviewed to present a current view of the mechanisms of conduction block by local anesthetics. Local anesthetics block the sodium channels whose opening causes the rising phase of the action potential.
Gary R. Strichartz
core   +1 more source

Comparison of the efficacy of saline, local anesthetics, and steroids in epidural and facet joint injections for the management of spinal pain: A systematic review of randomized controlled trials

Surgical neurology international, 2015
Background: The efficacy of epidural and facet joint injections has been assessed utilizing multiple solutions including saline, local anesthetic, steroids, and others.
L. Manchikanti, D. Nampiaparampil, Kavita N. Manchikanti, F. Falco, V. Singh, Ramsin M. Benyamin, A. Kaye, N. Sehgal, A. Soin, Thomas T. Simopoulos, S. Bakshi, C. Gharibo, C. Gilligan, J. Hirsch   +13 more
semanticscholar   +1 more source

Inhibitory effects of local anesthetics on the proteasome and their biological actions [PDF]

Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its ...
ヒサトメ, イチロウ, 河田, 康志, イトウ, トシユキ, イノウエ, マサシ, 山口, 博司, Bahrudin, Udin, Obara, Yuji, ニノミヤ, ハルアキ, 1457, Yamaguchi, Hiroshi, 李, 佩俐, バフルディン, ウディン, ヤマグチ, ヒロシ, Saeki, Yasushi, 40464292, 加藤, 克, リ, ペイリ, Kita, Akiko, Tsujitani, Shunichi, Inoue, Masashi, 27414, Ninomiya, Haruaki, 27415, 27418, 27419, 27416, 27417, Li, Peili, 3805, 30304207, 765, 100000877, Kato, Masaru, ツジタニ, シュンイチ, 二宮, 治明, Hisatome, Ichiro, 27425, 井上, 雅史, 27426, 27423, 27424, 27429, 100000183, Morimoto, Yukio, 27427, 27428, 40467709, 27421, 27422, Sakane, Isao, 27420, 100000348, 伊藤, 敏幸, 2609, Nishio, Kazuya, 100000307, 1879, Itoh, Toshiyuki, Murakami, Takuto, Unno, Masaki, 60211504, Kawata, Yasushi, Sugiyama, Rina, カトウ, マサル, カワタ, ヤスシ, 80212124, 100000496, 1367, 100000212, Tanaka, Keiji, 27430, 久留, 一郎, 27431, 40177697   +73 more
core   +1 more source

Disputed issues of systemic toxicity of local anesthetics

, 2020
Objective: assessment of the "systemic toxicity of local anesthetics,” term validity, and a legal appraisal of the term “lipid resuscitation.” Regulatory documents and specialized literature devoted to the terminology of toxicity of local anesthetics ...
V. V. Unzhakov, E. S. Netesin, V. I. Gorbachev   +2 more
core   +1 more source

Direct Inhibition of Microtubule-Based Kinesin Motility by Local Anesthetics

, 2000
Local anesthetics are known to inhibit neuronal fast anterograde axoplasmic transport (FAAT) in a reversible and dose-dependent manner, but the precise mechanism has not been determined.
Yanagida, Toshio, Miyamoto, Yoshikazu, Muto, Etsuko, Mashimo, Takashi, Yoshiya, Ikuto, Iwane, Atsuko H.   +5 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study from the EUSTAR Cohort

Arthritis Care &Research, Accepted Article.
Objective JAK inhibitors (JAKis) have shown promising effects in early‐phase studies of SSc. We aimed to assess the safety and explore effectiveness of JAKis compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the EUSTAR cohort was performed.
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P Denton, Madelon C Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Bupivacaína racêmica a 0,5% e mistura com excesso enantiomérico de 50% (S75-R25) a 0,5% no bloqueio do plexo braquial para cirurgia ortopédica. Estudo comparativo Bupivacaína racémica a 0,5% y mezcla con exceso enantiomérico del 50% (S75-R25) a 0,5% en el bloqueo del plexo braquial para cirugía ortopédica. Estudio comparativo Comparative study of 0.5% racemic bupivacaine versus enantiomeric mixture (S75-R25) of 0.5% bupivacaine in brachial plexus block for orthopedic surgery

Revista Brasileira de Anestesiologia, 2005
JUSTIFICATIVA E OBJETIVOS: Com a finalidade de encontrar uma droga mais segura que a bupivacaína racêmica, vários estudos foram realizados com seus isômeros.
Roberto Tsuneo Cervato Sato, Douglas Flávio Porsani, Antônio Garibaldino Vieira do Amaral, Oscar Vilmar Schulz Júnior, Ângelo Manoel Grande Carstens   +4 more
doaj   +1 more source