Results 101 to 110 of about 5,904,600 (301)

Local Anesthetic “Resistance”

Pain Physician, 2003
The incidence of inadequate analgesia despite technically well performed injections led our clinic to prospectively test patients for response to a variety of local aesthetics. Skin testing was performed on the skin of the forearm away from the site of pathology. Patients were asked to identify "which is the most numb" of the skin wheals. Although most
openaire   +2 more sources

Cardiovascular and central actions of local anesthetics

, 2016
thesis has discussed the common cardiovascular and CNS toxicity problems which may be observed and how to treat them or even better, prevent them in a clinical situation. The importance of lipid solubility of the local anesthesias was discussed in great
Malik, Farhan Tariq
core  

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Efficacy of low-dose hypobaric anesthetics in spinal anesthesia for cesarean delivery: systematic review and meta-analysis

The Journal of Maternal-Fetal & Neonatal Medicine
Objective Many studies have compared the anesthetic effects of different doses of hypobaric local anesthetics (without glucose) in spinal anesthesia for cesarean sections.
Min Li, Guohao Xie, Lihua Chu, Yan Li
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Bupivacaína racêmica a 0,5% e mistura com excesso enantiomérico de 50% (S75-R25) a 0,5% no bloqueio do plexo braquial para cirurgia ortopédica. Estudo comparativo Bupivacaína racémica a 0,5% y mezcla con exceso enantiomérico del 50% (S75-R25) a 0,5% en el bloqueo del plexo braquial para cirugía ortopédica. Estudio comparativo Comparative study of 0.5% racemic bupivacaine versus enantiomeric mixture (S75-R25) of 0.5% bupivacaine in brachial plexus block for orthopedic surgery

Revista Brasileira de Anestesiologia, 2005
JUSTIFICATIVA E OBJETIVOS: Com a finalidade de encontrar uma droga mais segura que a bupivacaína racêmica, vários estudos foram realizados com seus isômeros.
Roberto Tsuneo Cervato Sato, Douglas Flávio Porsani, Antônio Garibaldino Vieira do Amaral, Oscar Vilmar Schulz Júnior, Ângelo Manoel Grande Carstens   +4 more
doaj   +1 more source

DETERMINATION BY^1H-NMR OF BINDING SITES OF LOCAL ANESTHETICS ON LIPID BILAYER MEMBRANE MODEL [PDF]

, 1994
P(論文)局所麻酔薬の作用機序についてはさまざまな仮説があるが,どの仮説も十分な説明をしていない。そこで我々は核磁気共鳴装置(NMR)を用いて,局所麻酔薬と神経膜モデルであるリン脂質二重膜との結合状態を検索した。この結果,局所麻酔薬分子中にある窒素原子とリン脂質二重膜の外側にある親水性部分の酸素原子とが静電結合をおこすことが分かった。また我々が作用持続時間の延長を目的に合成した,リドカインのエステル誘導体では窒素原子との結合に加えて,エステルカルボニル部分の酸素原子でも膜と結合することもわかった。さらに,
23966, MACHIDA, Minoru, KOKUBU, Masahiro, SHINYA, Noboru, ODA, Kazuaki, 23963, 23964, 23965   +7 more
core  

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Current Concepts of the Mechanism of Action of Local Anesthetics

, 1981
Recent experiments are reviewed to present a current view of the mechanisms of conduction block by local anesthetics. Local anesthetics block the sodium channels whose opening causes the rising phase of the action potential.
Gary R. Strichartz
core   +1 more source