Results 121 to 130 of about 5,904,600 (301)

Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication?

Therapeutic Advances in Drug Safety
The increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas, Janet Cristina Vázquez-Beltrán, María Soledad Romero-López, Oscar Olvera-Montaño, Lourdes Yolotzin Rodríguez-Herrera   +4 more
doaj   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Construction of model of pediatric nurses' willingness to adopt local anesthetics in clinical practice

Huli yanjiu
ObjectiveTo explore the influencing factors of pediatric nurses' willingness to adopt local anesthetics in clinical practice.MethodsA total of 251 pediatric nurses from 10 hospitals in Sichuan province were surveyed by a self⁃designed survey ...
ZHAO Liping, LIAO Limei, QI Ping, WANG Xue   +3 more
doaj  

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Clonidine versus other adjuncts added to local anesthetics for pediatric neuraxial blocks: a systematic review and meta-analysis

, 2018
Yang Yang,1,2 Ling-Yu Yu,3 Wen-Sheng Zhang1,2 1Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Anesthesiology, West
Yang Y, Zhang WS, Yu LY
core  

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Inhibitory effects of local anesthetics on the proteasome and their biological actions [PDF]

Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its ...
ヒサトメ, イチロウ, 河田, 康志, イトウ, トシユキ, イノウエ, マサシ, 山口, 博司, Bahrudin, Udin, Obara, Yuji, ニノミヤ, ハルアキ, 1457, Yamaguchi, Hiroshi, 李, 佩俐, バフルディン, ウディン, ヤマグチ, ヒロシ, Saeki, Yasushi, 40464292, 加藤, 克, リ, ペイリ, Kita, Akiko, Tsujitani, Shunichi, Inoue, Masashi, 27414, Ninomiya, Haruaki, 27415, 27418, 27419, 27416, 27417, Li, Peili, 3805, 30304207, 765, 100000877, Kato, Masaru, ツジタニ, シュンイチ, 二宮, 治明, Hisatome, Ichiro, 27425, 井上, 雅史, 27426, 27423, 27424, 27429, 100000183, Morimoto, Yukio, 27427, 27428, 40467709, 27421, 27422, Sakane, Isao, 27420, 100000348, 伊藤, 敏幸, 2609, Nishio, Kazuya, 100000307, 1879, Itoh, Toshiyuki, Murakami, Takuto, Unno, Masaki, 60211504, Kawata, Yasushi, Sugiyama, Rina, カトウ, マサル, カワタ, ヤスシ, 80212124, 100000496, 1367, 100000212, Tanaka, Keiji, 27430, 久留, 一郎, 27431, 40177697   +73 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Effects of Local Anesthetics on Articular Cartilage

, 2011
Background: Recent basic science studies have demonstrated local anesthetic chondrotoxicity in vivo and in vitro in both human and animal cartilage. Clinically, chondrolysis associated with the use of intra-articular local anesthetic pain pumps has been
Jonathan D. Kramer, Samantha L. Piper, Hubert T. Kim, Brian T. Feeley   +3 more
core   +1 more source