Trial watch: local anesthetics in cancer therapy
OncoImmunologyPreclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost +3 more
doaj +2 more sources
Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors
Molecules, 2021 Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures.
John K. Neubert +9 more
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Local Anesthetics Induce Apoptosis in Human Breast Tumor Cells
Anesthesia and Analgesia, 2014 BACKGROUND: Previous studies have shown that local anesthetics may induce apoptosis in some cell types. In this study, we investigated the apoptotic effects of local anesthetics in human breast tumor cells.
Yuan-Ching Chang +8 more
semanticscholar +2 more sources
Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]
Jichu yixue yu linchuang, 2022 Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
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Pain management via local anesthetics and responsive hydrogels
Therapeutic delivery, 2015 Acute and chronic pain control is a significant clinical challenge that has been largely unmet. Local anesthetics are widely used for the control of post-operative pain and in the therapy of acute and chronic pain.
Kyle R. Bagshaw +6 more
semanticscholar +2 more sources
Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer
Frontiers in Oncology, 2022 Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang +9 more
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Analgesic protocol for procedural pain treatment of second-degree burns in children [PDF]
Vojnosanitetski Pregled, 2023 Background/Aim. Children with burns are submitted to multiple painful and anxiety-related procedures during the change of wound dressing, treatment, and rehabilitation.
Komarčević Aleksandar +4 more
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Potential Impact of Local Anesthetics Inducing Granulocyte Arrest and Altering Immune Functions on Perioperative Outcome [PDF]
, 2021 Introduction: Local anesthetics (LAs) are frequently used during anesthesia; however, they may influence granulocyte function which in turn could modify immune responses in the perioperative period. Therefore, the aim of this study was to investigate the
Pfaehler, Sophie-Marie +8 more
core +1 more source
Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics
Heliyon, 2023 Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan +4 more
doaj +1 more source
Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends
Saudi Journal of Anaesthesia, 2020 In recent anesthetic practice, peripheral nerve blocks (PNBs) are used extensively for surgical anesthesia and nonsurgical analgesia. PNBs offer many benefits over other anesthetic techniques in a certain population of patients, and in some specific ...
G. Krishna Prasad +2 more
semanticscholar +1 more source