Results 221 to 230 of about 302,831 (404)

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Role of Pharmacology in Dentistry: A Review of Analgesics, Antibiotics, and Local Anesthetics. [PDF]

Cureus
Datta A, Mukherjee B, Sood SK, Dutta S, Barve R, Pympallil U, Ravindran S.   +6 more
europepmc   +1 more source

PHARMACOLOGICAL ACTION OF ANESTHETIC AGENTS IN IRRADIATED ANIMALS [PDF]

, 1955
James Wilson
openalex   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

From neurotoxicity to neuroprotection: Rethinking GABA_AR-targeting anesthetics. [PDF]

Cell Biol Toxicol
Li Y, Yang H, Liu L, Jiang L, Xie P, Wang X, Cong X, Zhu R, Lu Z, Sun M, Zhang J.   +10 more
europepmc   +1 more source

PENETRANCE OF LOCAL ANESTHETICS [PDF]

, 1953
Theodore G. Brown, F.P. Ludueña
openalex   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Rapid Health Evaluation of Analgesia with Long-Acting Local Anesthesia After Hip and Knee Arthroplasty. [PDF]

Integr Pharm Res Pract
Zhang X, Li M, Lei L.
europepmc   +1 more source

Group Sensitivity to Local Anesthetics

, 1947
Maurice J. Strauss
openalex   +1 more source

WATER EXCHANGES DUE TO ANESTHETIC DRUGS [PDF]

, 1940
Henry G. Barbour
openalex   +1 more source